ChemicalBook > CAS DataBase List > 3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

Product Name
3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
CAS No.
514-62-5
Chemical Name
3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
Synonyms
8,11,13-Abietatriene-12-ol;abieta-8,11,13-triene-12-ol;(+)-8,11,13-Abietatrien-12-ol;(4bS)-4b,5,6,7,8,8aβ,9,10-Octahydro-4b,8,8-trimethyl-2-isopropylphenanthren-3-ol;(4aS)-1,1,4aβ-Trimethyl-7-isopropyl-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-6-ol;3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
CBNumber
CB21211375
Molecular Formula
C20H30O
Formula Weight
286.45
MOL File
514-62-5.mol
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3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Property

Melting point:
56-57℃
Boiling point:
388.1±31.0 °C(Predicted)
Density 
0.988±0.06 g/cm3 (20 ºC 760 Torr)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
10.89±0.60(Predicted)
color 
White to off-white
optical activity
+40.616 (c4, ethanol)
InChI
InChI=1S/C20H30O/c1-13(2)15-11-14-7-8-18-19(3,4)9-6-10-20(18,5)16(14)12-17(15)21/h11-13,18,21H,6-10H2,1-5H3/t18-,20+/m0/s1
InChIKey
QXNWVJOHUAQHLM-AZUAARDMSA-N
SMILES
C1=C2C([C@]3(C)[C@@]([H])(CC2)C(C)(C)CCC3)=CC(O)=C1C(C)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN92178
Product name
Ferruginol
Purity
≥98%
Packaging
5mg
Price
$418
Updated
2021/12/16
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3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Chemical Properties,Usage,Production

Uses

Ferruginol can be used for its antibacterial activities.

Definition

ChEBI: Ferruginol is an abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12. It has a role as an antineoplastic agent, an antibacterial agent, a protective agent and a plant metabolite. It is an abietane diterpenoid, a member of phenols, a carbotricyclic compound and a meroterpenoid.

in vivo

Ferruginol (20 mg/kg; p.o.; daily; for 4 weeks) exerts cardioprotection manifested as enhanced cardiac function and reduced structural damage and apoptosis. The transcriptome and other results revealed that Ferruginol facilitates PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation (MB and FAO) by increasing the expression of PGC-1α and concurrently promoting the expression of SIRT1-enhancing deacetylase SIRT1 deacetylating and activating PGC-1α[3].

Animal Model:Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)[3].
Dosage:20 mg/kg
Administration:Administered intragastrically; daily; for 4 weeks
Result:Relieved Doxorubicin-induced cardiac structural and functional lesion.

target

PARP | Bcl-2/Bax | Caspase | Antifection

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Suppliers

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514-62-5, 3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-Related Search:

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  • 3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
  • (+)-8,11,13-Abietatrien-12-ol
  • (4aS)-1,1,4aβ-Trimethyl-7-isopropyl-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-6-ol
  • (4bS)-4b,5,6,7,8,8aβ,9,10-Octahydro-4b,8,8-trimethyl-2-isopropylphenanthren-3-ol
  • 8,11,13-Abietatriene-12-ol
  • abieta-8,11,13-triene-12-ol
  • 514-62-5