3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid
- Product Name
- 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid
- CAS No.
- 23028-17-3
- Chemical Name
- 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid
- Synonyms
- (Rac)-Danshensu;Danshensu lactic acid;(Rac)-Salvianic acid A;α-Hydroxyhydrocaffeic acid;3,4-dihydroxyphenyllactic acid;3-(3,4-Dihydroxyphenyl)lactic acid;α,3,4-Trihydroxybenzenepropionic acid;α,3,4-Trihydroxybenzenepropanoic acid;α,3,4-trihydroxy-Benzenepropanoic acid;Benzenepropanoic acid, α,3,4-trihydroxy-
- CBNumber
- CB41235429
- Molecular Formula
- C9H10O5
- Formula Weight
- 198.17
- MOL File
- 23028-17-3.mol
3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid Property
- Boiling point:
- 481.5±40.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3 (20 ºC 760 Torr)
- pka
- 3.82±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- LogP
- 0.045 (est)
3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid Chemical Properties,Usage,Production
Uses
(Rac)-Salvianic acid A is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].
Definition
ChEBI: 3-(3,4-dihydroxyphenyl)lactic acid is a 2-hydroxy monocarboxylic acid and a member of catechols. It is functionally related to a rac-lactic acid. It is a conjugate acid of a 3-(3,4-dihydroxyphenyl)lactate.
References
[1] Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. DOI:10.1038/s41401-021-00714-4
[2] V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. DOI:10.3389/fendo.2020.568436
[3] Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. DOI:10.1016/j.biopha.2021.111995
3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid Preparation Products And Raw materials
Raw materials
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