5,10-Methylene-THF

Product Name: 5,10-Methylene-THF
CAS No.: 31690-11-6
Chemical Name: 5,10-Methylene-THF
Synonyms: 5,10-Methylene-THF;Folinic Acid Impurity 7;Folic Acid EP Impurity I;Levofolinate EP Impurity I;Folinic Acid EP Impurity I;(S)-2-(4-((R)-3-amino-1-oxo;Calcium Levofolinate EP Impurity I;(6R) 5,10-Methylenetetrahydrofolate;(6aR)-5,10-Methylenetetrahydrofolic Acid;N5,N10-Methylene-5,6,7,8-tetrahydrofolate
CBNumber: CB21235571
Molecular Formula: C20H23N7O6
Formula Weight: 457.44
MOL File: 31690-11-6.mol

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5,10-Methylene-THF Property

Density: 1.75±0.1 g/cm3(Predicted)
pka: 3.47±0.10(Predicted)
InChIKey: QYNUQALWYRSVHF-OLZOCXBDSA-N
SMILES: C(O)(=O)[C@H](CCC(O)=O)NC(=O)C1=CC=C(N2C[C@@]3([H])CNC4=C(N3C2)C(=O)NC(N)=N4)C=C1

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Hazard and Precautionary Statements (GHS)

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5,10-Methylene-THF Chemical Properties,Usage,Production

Uses

Arfolitixorin is a folate prodrug that is used in the treatment for colorectal cancer as a way for increase in efficacy and reducing the side effects of antimetabolites used in cancer treatment.

Definition

ChEBI: (6R)-5,10-methylenetetrahydrofolic acid is the (6R)-stereoisomer of 5,10-methylenetetrahydrofolic acid. It has a role as an Escherichia coli metabolite, a mouse metabolite and a cofactor. It is a conjugate acid of a (6R)-5,10-methylenetetrahydrofolate(2-).

5,10-Methylene-THF Preparation Products And Raw materials

Raw materials

Preparation Products

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5,10-Methylene-THF Suppliers

China 26 India 3 United States 3 Global 32

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31690-11-6, 5,10-Methylene-THFRelated Search:

(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid 10-Formylfolic Acid 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid Folinic Acid IMpurity E Calcium levofolinate 10-formyldihydrofolate

5,10-Methylene-THF

(6R) 5,10-Methylenetetrahydrofolate

5,10-Methylene-THF// (S)-2-(4-((R)-3-Amino-1-oxo-5,6,6a,7-tetrahydro imidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzami do)pentanedioic acid

N5,N10-Methylene-5,6,7,8-tetrahydrofolate

(S)-2-(4-((R)-3-amino-1-oxo

(S)-2-(4-((R)-3-Amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid

L-Glutamic acid, N-[4-[(6aR)-3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl]-

Folinic Acid EP Impurity I

Folinic Acid Impurity 7

Calcium Levofolinate EP Impurity I

Levofolinate EP Impurity I

(6aR)-5,10-Methylenetetrahydrofolic Acid

Folic Acid EP Impurity I

Calcium Levofolinate Impurity 10 (Calcium Levofolinate EP Impurity I)

Levofolinate EP Impurity I（Folic Acid EP Impurity I）

31690-11-6

C20H23N7O6