2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid

Product Name: 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
CAS No.: 516-90-5
Chemical Name: 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
Synonyms: Lithocholyltaurine;Apigenine Impurity 6;Cholic acid Impurity 72;Taurolithocholic Acid D8;Taurodeoxycholic Acid Impurity 3;Lithocholic acid taurine conjugate;Taurolithocholic Acid MaxSpec? Standard;N-(3α-Hydroxy-24-oxo-5β-cholan-24-yl)taurine;5β-CHOLANIC ACID-3α-OL N-(2-SULPHOETHYL)-AMIDE;Taurolithocholic Acid Standard (solution in methanol)
CBNumber: CB21236073
Molecular Formula: C26H45NO5S
Formula Weight: 483.7
MOL File: 516-90-5.mol

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2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid Property

Melting point:: 212-213 °C
Density: 1.0476 (rough estimate)
refractive index: 1.5650 (estimate)
storage temp.: -20°C
form: powder
pka: 1.42±0.50(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: SHG0007272
Product name: TAUROLITHOCHOLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $495.84
Updated: 2021/12/16

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2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid Chemical Properties,Usage,Production

Uses

Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cell cycle, and promoting DNA synthesis in a concentration-dependent manner in the intrahepatic cholangiocarcinoma cell line RMCCA-1. It can also increase the phosphorylation of EGFR and ERK 1/2 and the expression of cyclin D1 in RMCCA-1 cells, and its induced RMCCA-1 cell growth can be inhibited by specific antagonists and inhibitors.

Definition

ChEBI: Taurolithocholic acid is the bile acid taurine conjugate of lithocholic acid. It has a role as a human metabolite. It is a monocarboxylic acid amide and a bile acid taurine conjugate. It is functionally related to a lithocholic acid. It is a conjugate acid of a taurolithocholate.

IC 50

Human Endogenous Metabolite

References

[1] High Frequency Technique for Continuous Recording in Chromatographic Analysis of Bile Acids

2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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516-90-5, 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acidRelated Search:

Taurohyodeoxycholic acid sodium salt hydrate taurohyodeoxycholic acid Taurohyodeoxycholic Acid-d5 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Taurohyodeoxycholic Acid Sodium Salt-d5 Taurohyodeoxycholic Acid Sodium Salt Impurity 1 Tauroursodeoxycholic acid

Lithocholyltaurine

2-[(3α-Hydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid

N-(3α-Hydroxy-24-oxo-5β-cholan-24-yl)taurine

Ethanesulfonic acid, 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-

Taurolithocholic Acid MaxSpec? Standard

Taurolithocholic Acid D8

Taurolithocholic acidQ: What is Taurolithocholic acid Q: What is the CAS Number of Taurolithocholic acid

Lithocholic acid taurine conjugate

Taurodeoxycholic Acid Impurity 3

5β-CHOLANIC ACID-3α-OL N-(2-SULPHOETHYL)-AMIDE

Apigenine Impurity 6

Cholic acid Impurity 72

Taurolithocholic Acid Standard (solution in methanol)

2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid

516-90-5

C26H45NO5S