ChemicalBook > CAS DataBase List > 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

Product Name
2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
CAS No.
516-50-7
Chemical Name
2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
Synonyms
Taurodesoxycholic Acid;Tudcabil;Deoxycholyltaurine;Taurodoxcholicacid;Apigenine Impurity 3;Deoxytaurocholic Acid;Taurodeoxychloic Acid;Taurine deoxycholic acid;Taurosulfodeoxycholic acid;Taurodesoxycholic Acid(TDCA)
CBNumber
CB51236276
Molecular Formula
C26H45NO6S
Formula Weight
499.7
MOL File
516-50-7.mol
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2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Property

Melting point:
175-200 °C
Density 
1.216±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
1.42±0.50(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
BBF0000260
Product name
TAURODEOXYCHOLIC ACID
Purity
95.00%
Packaging
5MG
Price
$496.3
Updated
2021/12/16
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2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Chemical Properties,Usage,Production

Uses

Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Definition

ChEBI: A bile acid taurine conjugate of deoxycholic acid.

in vivo

Taurodeoxycholic acid (1.25-5 mg/kg, p.o., 6 days) ameliorates dextran sodium sulfate (DSS)-induced colitis in mice[9].
Taurodeoxycholic acid (Taurodeoxycholic acid form, 50 mg/kg; i.p.; once daliy for 34 d) prevents neuropathology and associated behavioral deficits in the 3-nitropropionic acid rat model of Huntington's disease (HD) [10].
Taurodeoxycholic acid (Taurodeoxycholic acid form, 500 mg/kg; s.c.; once every 3 d for 7 weeks) leads to a significant reduction in striatal neuropathology of the R6/2 transgenic HD mouse[11].
Taurodeoxycholic acid (0.5 mg/kg; i.v., once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis[12].

Animal Model:A mouse colitis model (fed with 3% (w/v) DSS in drinking water for the first seven days and then switched to normal drinking water for an additional two days)[9]
Dosage:1.25, 2.5, and 5 mg/kg
Administration: Oral gavage (p.o.), from day 3 to day 8, once a day
Result:Prevented loss of body weight, shortening of the colon, production of pro-inflammatory cytokines, infiltration of pro-inflammatory cells, and mucosal ulceration in the colon.
Animal Model: Huntington's disease model in mouse[10]
Dosage:50 mg/kg
Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.
Significantly improved locomotor and sensorimotor deficits.
Animal Model:C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[12]
Dosage: 0.5 mg/kg
Administration:Intravenous injection, 30 min or 24 h after LPS injection
Result:Improved the survival rate of mice with sepsis.
Decreased liver and kidney damage in septic mice.
Ameliorated systemic inflammation and normalized blood pressure in septic mice.

IC 50

Microbial Metabolite

2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Suppliers

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View Lastest Price from 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid 516-50-7
Price
US $3.00/kg
Min. Order
1kg
Purity
99.99
Supply Ability
10000
Release date
2025-06-05
Shaanxi Xianhe Biotech Co., Ltd
Product
Taurodeoxycholic acid 516-50-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-21

516-50-7, 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acidRelated Search:

Taurohyodeoxycholic acid sodium salt hydrate taurohyodeoxycholic acid Taurohyodeoxycholic Acid-d5 Taurohyodeoxycholic Acid Sodium Salt-d5 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid Taurohyodeoxycholic Acid Sodium Salt Impurity 1 Tauroursodeoxycholic acid

  • 2-[[(3a,5,12)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid
  • Deoxycholyltaurine
  • Deoxytaurocholic Acid
  • N-(3a,12a-Dihydroxy-5-cholan-24-oyl)taurine
  • Taurodeoxychloic Acid
  • Taurodesoxycholic Acid
  • Tudcabil
  • 2-[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid
  • N-(2-Sulfoethyl)-3α,12α-dihydroxy-5β-cholan-24-amide
  • Taurodeoxychloic Acid Discontinued See T009005
  • 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
  • Ethanesulfonic acid, 2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-
  • 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid
  • Taurodeoxycholic Acid MaxSpec? Standard
  • Taurodeoxycholic Acid Discontinued See T009005
  • Taurosulfodeoxycholic acid
  • Taurodesoxycholic Acid(TDCA)
  • Taurodeoxycholic Acid Monomer
  • Taurine isoursodeoxycholic acid
  • Taurine deoxycholic acid
  • Apigenine Impurity 3
  • Taurodoxcholicacid
  • Taurodeoxycholic Acid (solution in methanol) Standard
  • 516-50-7
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids