Penconazole Property

Melting point:

58.5 °C

Boiling point:

436.06°C (rough estimate)

Density 

1.2556 (rough estimate)

vapor pressure 

3.7 x l0^-4 Pa (25 °C)

refractive index 

1.6300 (estimate)

Flash point:

100 °C

storage temp. 

0-6°C

solubility 

DMSO: 100 mg/mL (351.89 mM)

pka

2.80±0.10(Predicted)

form 

Solid

Water Solubility 

73 mg l^-1 (25 °C)

color 

White

BRN 

541488

LogP

3.660 (est)

CAS DataBase Reference

66246-88-6(CAS DataBase Reference)

EPA Substance Registry System

Penconazole (66246-88-6)

Safety

Safety Statements 

22-24/25

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

2

RTECS 

XZ4615000

HS Code 

29339900

Toxicity

LD50 skn-rat: >3 g/kg DOVEAA 38,195,84

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

Penconazole Chemical Properties,Usage,Production

Uses

Penconazole is used for the control of powdery mildew, pome fruit scab and other pathogenic Ascomycetes, Basidiomycetes and Deuteromycetes on vines, cucurbits, pome fruit, stone fruit, ornamentals, hops, tobacco and vegetables.

Uses

Penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.

Definition

ChEBI: 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole is a member of the classof triazoles that is 1,2,4-triazole substituted at position 1 by a 2-(2,4-dichlorophenyl)pentyl group. It is a dichlorobenzene and a member of triazoles.

Agricultural Uses

Fungicide: Penconazole is a systemic fungicide used to control powdery mildew. It is used on apples and grapes and other fruits, hops, tobacco, ornamentals and on vegetables. Not currently registered in the U.S. Reported to be used in most European countries. Currently, there are more than 30 global suppliers.

Trade name

AWARD®; CGA-71818®; ONMEX®; TOPAS®; TOPAS-C®; TOPAS-MZ®; TOPAZ®; TOPAZE®; TOPAZE-C®; TOPENCO 100EC®

Safety Profile

Moderately toxic by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx and Clí.

Metabolic pathway

Penconazole is metabolised in plants by hydroxylation of the propyl side chain and conjugation or metabolism to triazolylalanine and triazolylacetic acid. It is quite persistent in soils but degradation by sunlight requires only a few days. It is eliminated rapidly from mammals.

Degradation

Penconazole (1) is stable to hydrolysis at pH 1-13 and at temperatures up to 350 °C. It is degraded in sunlight with a DT₅₀ of 4 days in natural sunlight. Its photochemical reactions have been studied. On irradiation with light of wavelengths greater than 280 nm (high-pressure mercury lamp with filter), the major reaction was the formation of a cyclised product (2) (Scheme 1). Irradiation under the same conditions in isopropanol gave mainly 2 and 3 (a dechlorinated product). After 8 hours, yields were 29.8% of 2 and 12.3% of 3 respectively. The product 3 alone photodegraded only slowly but 2 was completely photolysed within 3 hours to further products, indicating its role as an intermediate in the photolytic pathways (Schwack and Hartmann, 1992, 1994). In the presence of isopropanol, photodehalogenation of 3 to 4 competed with substitution of a solvent molecule to give a low yield (