ChemicalBook > CAS DataBase List > (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

Product Name
(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
CAS No.
156722-18-8
Chemical Name
(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
Synonyms
CS-906;PST2238;17-triol;AC1L4BGU;Rostafuroxin;CHEMBL2068971;SureCN1716210;UNII-P848LCX62B;PST 2238, >=98%;PST2238,Rostafuroxin
CBNumber
CB21253997
Molecular Formula
C23H34O4
Formula Weight
374.51
MOL File
156722-18-8.mol
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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Property

Boiling point:
451.3±45.0 °C(Predicted)
Density 
1.226±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥12.05 mg/mL in DMSO
form 
solid
pka
14.02±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21282
Product name
Rostafuroxin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21282
Product name
Rostafuroxin
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
21282
Product name
Rostafuroxin
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
21282
Product name
Rostafuroxin
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
Tocris
Product number
5315
Product name
Rostafuroxin
Purity
≥98%(HPLC)
Packaging
10
Price
$210
Updated
2021/12/16
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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Chemical Properties,Usage,Production

Description

Rostafuroxin potently inhibits binding of endogenous ouabain to the Na+/K+ ATPase (IC50 = 1.7 μM) through the Src-epidermal growth factor receptor (EGFR)-dependent signaling pathway. This blocks the ouabain-dependent increase in Na+/K+ ATPase activity. In cultured renal cells where the Na+/K+ ATPase is upregulated or has increased activity, rostafuroxin normalizes mRNA levels and Na+/K+ ATPase activity. At very low doses (1 and 10 μg/kg for 5-6 weeks) in Milan-hypertensive rats, it decreased the development of hypertension. In a Phase II clinical study, rostafuroxin did not reduce blood pressure in human patients at doses of 0.05-5.0 mg/d.

Uses

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol is used as a receptor blocker in the treatment of hypertension.

in vitro

at molecular level, in the kidney, rostafuroxin antagonizes eo by triggering of the src-epidermal growth factor receptor (egfr)-dependent signaling pathway leading to renal na+-k+ pump, and erk tyrosine phosphorylation and activation. in the vasculature, it normalizes the increased myogenic tone caused by nanomolar ouabain [1].

in vivo

rostafuroxin reduces blood pressure without affecting heart rate, and restores the normal activity of the renal na+-k+-atpase in mhs rats when orally treated at doses from 1 to 100 μg/kg/day. similarly, nua rats have their blood pressure normalized by rostafuroxin [1].

IC 50

2 μm for na+-k+-atpase

storage

Store at +4°C

References

[1] ferrari p, ferrandi m, valentini g, bianchi g. rostafuroxin: an ouabain antagonist that corrects renal and vascular na+-k+-atpase alterations in ouabain and adducin-dependent hypertension. am j physiol regul integr comp physiol. 2006 mar;290(3):r529-35.

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Preparation Products And Raw materials

Raw materials

Preparation Products

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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Suppliers

China 63 India 1 United Kingdom 2 United States 14 Global 80
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Rostafuroxin 156722-18-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Rostafuroxin 156722-18-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

156722-18-8, (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triolRelated Search:


  • (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
  • Rostafuroxin
  • PST2238
  • (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
  • Rostafuroxin (PST-2238)
  • (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
  • Rostafuroxin PST2284
  • (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238)
  • CS-906
  • 17-β-(3-furyl)-5-β-androstane-3-β, 14-β, 17-α-triol
  • 17-(3-Furyl)-5beta-androstane-3
  • 17-triol
  • AC1L4BGU
  • CHEMBL2068971
  • PST 2238; PST-2238; AC1L4BGU; SURECN1716210; UNII-P848LCX62B; 17-(3-FURYL)-5BETA-ANDROSTANE-3;14;17-TRIOL; CHEMBL2068971; 156722-18-8
  • SureCN1716210
  • UNII-P848LCX62B
  • Rostafuroxin (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
  • PST 2238, >=98%
  • PST2238,Rostafuroxin
  • 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
  • 24-Norchola-20,22-diene-3,14,17-triol,21,23-epoxy-, (3b,5b,14b)-
  • Rostafuroxin,ATP1A1,RSV,PST-2238,Respiratory syncytial virus,Na+/K+ ATPase,phosphorylation,inhibit,PST2238,Tyr845,Sodium potassium pump,EGFR,antihypertensive,RSV-GFP,Inhibitor,digitoxigenin,Ouabain
  • (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
  • (3S,5R,8R,9S,10S,13S,14S,17S)-17-(Furan-3-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
  • (1S,3aS,3bR,5aR,7S,9aS,9bS,11aS)-1-(furan-3-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthrene-1,3a,7-triol
  • 156722-18-8
  • Inhibitors