Eflornithine hydrochloride hydrate

Product Name: Eflornithine hydrochloride hydrate
CAS No.: 96020-91-6
Chemical Name: Eflornithine hydrochloride hydrate
Synonyms: Vaniqa;Unii-4nh22ndw9h;DFMO EFLORNITHINE;Eflornithine HCl API;Eflornithine HCl hydrate;DMFO HCl/Eflornithine HCl;Eflornithine HCl Monohydrate;Eflornithine HCl hydrate (DFMO;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate
CBNumber: CB21261062
Molecular Formula: C6H15ClF2N2O3
Formula Weight: 236.64
MOL File: 96020-91-6.mol

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Eflornithine hydrochloride hydrate Property

Melting point:: >210°C (dec.)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in Water (up to 25 mg/ml).
form: White powder
color: White
Merck: 14,3522
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference: 96020-91-6

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Safety

RTECS: RM2981900
HS Code: 2922493800

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1234249
Product name: Eflornithine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150MG
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: E0947
Product name: Eflornithine Hydrochloride Monohydrate
Purity: >98.0%(T)
Packaging: 200mg
Price: $247
Updated: 2024/03/01

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 25mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 50mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 100mg
Price: $75
Updated: 2024/03/01

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Eflornithine hydrochloride hydrate Chemical Properties,Usage,Production

Description

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.

Chemical Properties

White Solid

Uses

Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.

Definition

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

General Description

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Biochem/physiol Actions

Primary TargetODC

References

1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945

Eflornithine hydrochloride hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Eflornithine hydrochloride hydrate Suppliers

Americas 1 Canada 1 China 147 Europe 1 India 28 Japan 2 Switzerland 1 United Kingdom 2 United States 21 Global 204

MedChemexpress LLC

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View Lastest Price from Eflornithine hydrochloride hydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $1.00/g
Min. Order: 10g
Purity: 98.0%～ 102.0%
Supply Ability: 200kg/month
Release date: 2021-06-10

Henan Aochuang Chemical Co.,Ltd.

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

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Eflornithine HCl hydrate (DFMO

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Eflornithine Hydrochloride (1234249)

2-(difluoromethyl)-Ornithine hydrochloride hydrate (1:1:1)

96020-91-6

C6H12F2N2O2HClH2O

C6H15ClF2N2O3

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