ChemicalBook > CAS DataBase List > METHYL2-AMINO-3-FLUOROBENZOATE

METHYL2-AMINO-3-FLUOROBENZOATE

Product Name
METHYL2-AMINO-3-FLUOROBENZOATE
CAS No.
144851-82-1
Chemical Name
METHYL2-AMINO-3-FLUOROBENZOATE
Synonyms
METHYL2-AMINO-3-FLUOROBENZOATE;2-Amino-3-fluorobenzoic acid methyl ester;Benzoic acid, 2-aMino-3-fluoro-, Methyl ester;2-amino-3-fluoro-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 2-amino-3-fluoro-, methyl ester (9CI, ACI)
CBNumber
CB21265297
Molecular Formula
C8H8FNO2
Formula Weight
169.15
MOL File
144851-82-1.mol
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METHYL2-AMINO-3-FLUOROBENZOATE Property

Boiling point:
247℃
Density 
1.264
Flash point:
103℃
storage temp. 
2-8°C(protect from light)
pka
0.80±0.10(Predicted)
Appearance
Yellow to brown Solid
InChI
InChI=1S/C8H8FNO2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,10H2,1H3
InChIKey
ISLOQGNBENYQQF-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=CC(F)=C1N
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M328778
Product name
Methyl2-amino-3-fluorobenzoate
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FM64244
Product name
2-Amino-3-fluorobenzoic acid methyl ester
Packaging
250mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
076170
Product name
Methyl 2-amino-3-fluorobenzoate
Purity
95+%
Packaging
1g
Price
$67
Updated
2021/12/16
Biosynth Carbosynth
Product number
FM64244
Product name
2-Amino-3-fluorobenzoic acid methyl ester
Packaging
500mg
Price
$95
Updated
2021/12/16
Apolloscientific
Product number
PC53196
Product name
Methyl2-amino-3-fluorobenzoate
Packaging
1g
Price
$109
Updated
2021/12/16
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METHYL2-AMINO-3-FLUOROBENZOATE Chemical Properties,Usage,Production

Uses

Methyl 2-amino-3-fluorobenzoate

Synthesis

67-56-1

825-22-9

144851-82-1

General procedure for the synthesis of methyl 2-amino-3-fluorobenzoate from methanol and 2-amino-3-fluorobenzoic acid: 1. a mixture of 2-amino-3-fluorobenzoic acid (559 mg, 3.62 mmol) and 1.7 mL of concentrated H2SO4 in 11 mL of anhydrous methanol was heated and refluxed for 66 hours. 2. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove methanol. 3. The residue was dissolved in 30 mL of water and transferred to a dispensing funnel. 4. Slowly add solid sodium carbonate to neutralize to pH 9-10 until no gas escapes. 5. 5. Extract the aqueous layer with ethyl acetate (3 x 40 mL). 6. The organic layers were combined and washed sequentially with 100 mL of saturated aqueous NaHCO3 and 100 mL of brine. 7. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. 8. The product was purified by column chromatography (eluent: 5% ethyl acetate in hexane) to give Intermediate 10 (491 mg, 80% yield) as a white solid. 9. 9. Characterization of the product: 1H-NMR (CDCl3, 300 MHz) δ: 7.66-7.63 (m, 1H), 7.15-7.08 (m, 1H), 6.60-6.55 (m, 1H), 5.40 (br s, 2H), 3.89 (s, 3H); LCMS m/z [M+H]+ calculated C8H8FNO2: 170.05, measured value. 170.05, measured value: 170.10.

References

[1] Patent: WO2011/163518, 2011, A1. Location in patent: Page/Page column 158
[2] Patent: US2013/273037, 2013, A1. Location in patent: Paragraph 0808-0811
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1630 - 1643
[4] Patent: WO2009/27730, 2009, A1. Location in patent: Page/Page column 55
[5] Chemical Communications, 2018, vol. 54, # 90, p. 12766 - 12769

METHYL2-AMINO-3-FLUOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL2-AMINO-3-FLUOROBENZOATE Suppliers

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View Lastest Price from METHYL2-AMINO-3-FLUOROBENZOATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 2-amino-3-fluorobenzoate 144851-82-1
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-07
Career Henan Chemical Co
Product
METHYL2-AMINO-3-FLUOROBENZOATE 144851-82-1
Price
US $9.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

144851-82-1, METHYL2-AMINO-3-FLUOROBENZOATERelated Search:

Methyl Oleate 3,5-Diaminobenzoic acid Benzocaine

  • METHYL2-AMINO-3-FLUOROBENZOATE
  • 2-Amino-3-fluorobenzoic acid methyl ester
  • Benzoic acid, 2-aMino-3-fluoro-, Methyl ester
  • Benzoic acid, 2-amino-3-fluoro-, methyl ester (9CI, ACI)
  • 2-amino-3-fluoro-Benzoic acid methyl ester (9CI ACI)
  • 144851-82-1
  • 144851-82-4