Methylophiopogonanone A
- Product Name
- Methylophiopogonanone A
- CAS No.
- 74805-92-8
- Chemical Name
- Methylophiopogonanone A
- Synonyms
- Methylophiopogonanone A;R-Methylophiopogonanone A;8-Methylophiopogonanone A;Methylophiopogonanone A -RM;Methylophiopogonanone A (MO-A);Methylophiopogonanone A, 10 mM in DMSO;Methylophiopogonanone A(R-Methylophiopogonanone A);3-(benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one;(R)-3-(Benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
- CBNumber
- CB21267822
- Molecular Formula
- C19H18O6
- Formula Weight
- 342.34
- MOL File
- 74805-92-8.mol
Methylophiopogonanone A Property
- Boiling point:
- 580.1±50.0 °C(Predicted)
- Density
- 1.410
- storage temp.
- 2-8°C
- solubility
- Soluble in chloroform and methanol;
- form
- powder
- pka
- 8.24±0.40(Predicted)
- color
- Light yellow
- Water Solubility
- insoluble in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHL84060
- Product name
- Methylophiopogonanone A
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $453
- Updated
- 2025/07/31
- Product number
- 30192
- Product name
- Methylophiopogonanone A
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 30192
- Product name
- Methylophiopogonanone A
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- 30192
- Product name
- Methylophiopogonanone A
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 300629
- Product name
- Methylophiopogonanone A
- Packaging
- 10mg
- Price
- $450
- Updated
- 2021/12/16
Methylophiopogonanone A Chemical Properties,Usage,Production
Description
Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.
Chemical Properties
It is soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the hairy roots of Ophiopogon japonicus.
Uses
Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].
Definition
ChEBI: Methylophiopogonanone A is a homoflavonoid.
in vivo
Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury[1].
target
MMP(e.g.TIMP)
References
[1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun;37(6):763-71. DOI:10.1038/aps.2016.14
Methylophiopogonanone A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methylophiopogonanone A manufacturers
- Product
- Methylophiopogonanone A 74805-92-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-01
- Product
- Methylophiopogonanone A 74805-92-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-06
- Product
- Methylophiopogonone A 74805-92-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-06