ChemicalBook > CAS DataBase List > Methylophiopogonanone A

Methylophiopogonanone A

Product Name
Methylophiopogonanone A
CAS No.
74805-92-8
Chemical Name
Methylophiopogonanone A
Synonyms
Methylophiopogonanone A;R-Methylophiopogonanone A;8-Methylophiopogonanone A;Methylophiopogonanone A -RM;Methylophiopogonanone A (MO-A);Methylophiopogonanone A, 10 mM in DMSO;Methylophiopogonanone A(R-Methylophiopogonanone A);3-(benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one;(R)-3-(Benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
CBNumber
CB21267822
Molecular Formula
C19H18O6
Formula Weight
342.34
MOL File
74805-92-8.mol
More
Less

Methylophiopogonanone A Property

Boiling point:
580.1±50.0 °C(Predicted)
Density 
1.410
storage temp. 
2-8°C
solubility 
Soluble in chloroform and methanol;
form 
powder
pka
8.24±0.40(Predicted)
color 
Light yellow
Water Solubility 
insoluble in water
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL84060
Product name
Methylophiopogonanone A
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$453
Updated
2025/07/31
Cayman Chemical
Product number
30192
Product name
Methylophiopogonanone A
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30192
Product name
Methylophiopogonanone A
Packaging
10mg
Price
$301
Updated
2024/03/01
Cayman Chemical
Product number
30192
Product name
Methylophiopogonanone A
Packaging
5mg
Price
$169
Updated
2024/03/01
Usbiological
Product number
300629
Product name
Methylophiopogonanone A
Packaging
10mg
Price
$450
Updated
2021/12/16
More
Less

Methylophiopogonanone A Chemical Properties,Usage,Production

Description

Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the hairy roots of Ophiopogon japonicus.

Uses

Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].

Definition

ChEBI: Methylophiopogonanone A is a homoflavonoid.

in vivo

Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury[1].

target

MMP(e.g.TIMP)

References

[1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun;37(6):763-71. DOI:10.1038/aps.2016.14

Methylophiopogonanone A Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Methylophiopogonanone A Suppliers

China 174 Switzerland 1 United States 11 Global 186
BIOSYNTH AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
1308
Advantage
60
More
Less

View Lastest Price from Methylophiopogonanone A manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Methylophiopogonanone A 74805-92-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-01
Shanghai Standard Technology Co., Ltd.
Product
Methylophiopogonanone A 74805-92-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-06
Shanghai Standard Technology Co., Ltd.
Product
Methylophiopogonone A 74805-92-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-06

74805-92-8, Methylophiopogonanone ARelated Search:

Celosin H Glycoside O-4 (6S,7S,12aR)-5,6,7,8-Tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-1,7-diol OPHIOPOGONIN D Liriopeside B Crocin Luteolin Isoflavone Shikonin methyl protodioscin Methyl hesperidin Methylophiopogonanone B 5-18-05-00186 (Beilstein Handbook Reference) Methylophiopogonanone A OPHIOGONANONE A 2'-METHOXY-3-(3-METHOXYPHENYL)PROPIOPHENONE 3',5'-DIMETHYL-3-(3-METHOXYPHENYL)PROPIOPHENONE 3',5'-DIMETHYL-3-(4-METHOXYPHENYL)PROPIOPHENONE

  • Methylophiopogonanone A
  • (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
  • Methylophiopogonanone A(R-Methylophiopogonanone A)
  • 8-Methylophiopogonanone A
  • (3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
  • R-Methylophiopogonanone A
  • Methylophiopogonanone A (MO-A)
  • 4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-
  • 3-(benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one
  • Methylophiopogonanone A -RM
  • Methylophiopogonanone A, 10 mM in DMSO
  • (R)-3-(Benzo[d][1,3]dioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one
  • 74805-92-8
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract