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Estramustine sodium phosphate

Product Name
Estramustine sodium phosphate
CAS No.
52205-73-9
Chemical Name
Estramustine sodium phosphate
Synonyms
emcyt;C13031;Estracyt;NSC 89199;iumphosphate;Ro 21-8837/001;estracytsodium;4-(550-Butyl)phenol;Estramustin sodium phosphate;ESTRAMUSTINE PHOSPHATE SODIUM
CBNumber
CB2127417
Molecular Formula
C23H33Cl2NNaO6P
Formula Weight
544.38
MOL File
52205-73-9.mol
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Estramustine sodium phosphate Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
form 
A crystalline solid
Stability:
Hygroscopic, Unstable in Solution
CAS DataBase Reference
52205-73-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37
Safety Statements 
26
WGK Germany 
3
RTECS 
KG7350000
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E0407
Product name
Estramustine sodium phosphate
Packaging
25mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
E0407
Product name
Estramustine sodium phosphate
Packaging
5mg
Price
$46.4
Updated
2023/06/20
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
50mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
100mg
Price
$201
Updated
2024/03/01
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Estramustine sodium phosphate Chemical Properties,Usage,Production

Description

Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 μM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.

Uses

Estramustine phosphate sodium USP (Emcyt) is used to treat Prostatic carcinoma.

Uses

Estramustine sodium phosphate is binds estradiol receptors irreversibly.

Uses

Antineoplastic.

Definition

ChEBI: An organic sodium salt which is the disodium salt of estramustine phosphate.

brand name

Emcyt (Pharmacia & Upjohn).

General Description

Estramustine as the phosphate is available in 140-mg capsulesfor the treatment of prostate cancer. Although originallydesigned as an alkylating agent, it has been shown tobe devoid of alkylating activity and functions as an inhibitorof microtubule function by binding to microtubule associate proteins (MAPs) and also binds to tubulin at a site that isdistinct from that of the vinca alkaloids but thought to partiallyoverlap with that of pacilataxel.The major mechanismby which cells become resistant to the agent involvesincreased efflux, although this is not mediated by Pgp as isthe case with other microtubule inhibitors such as the taxanesand vinca alkaloids. Therefore, the agent does not showcross-resistance with these agents. As an inhibitor of microtubules,it is cell cycle specific acting in the M phase. Theagent is well absorbed upon oral administration with hydrolysisof the water solubilizing phosphate beginning to occurin the GI tract. Metabolism involves the formation of theactive estromustine, which arises from oxidation of the C17alcohol to give the ketone. Additional inactive metabolitesresult from carbamate hydrolysis to give estradiol and estrone.The parent and metabolites are primarily eliminatedin the feces with a terminal elimination half-life of 20 hours.The adverse effects of the agent are nausea and vomiting,which is generally mild but the severity may increase uponprolonged administration. Gynecomastia also commonlyoccurs, and diarrhea may also be seen. Less commonly seeneffects include myelosuppression, skin rash, and cardiovascularabnormalities including CHF.

Estramustine sodium phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Estramustine sodium phosphate Suppliers

Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
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View Lastest Price from Estramustine sodium phosphate manufacturers

Dideu Industries Group Limited
Product
Estramustine sodium phosphate 52205-73-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-05
Career Henan Chemical Co
Product
Estramustine sodium phosphate 52205-73-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-07

52205-73-9, Estramustine sodium phosphateRelated Search:


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