Estramustine
- Product Name
- Estramustine
- CAS No.
- 2998-57-4
- Chemical Name
- Estramustine
- Synonyms
- LEO 275;Estracty;NSC89201;NSC 89201;NSC-89201;Estamustine;Estramustin;ESTRAMUSTINE;Alestramustine;Estramustine USP/EP/BP
- CBNumber
- CB9127416
- Molecular Formula
- C23H31Cl2NO3
- Formula Weight
- 440.4
- MOL File
- 2998-57-4.mol
Estramustine Property
- Melting point:
- 104-105°
- alpha
- D20 +50° (in dioxane)
- Boiling point:
- 565.8±50.0 °C(Predicted)
- Density
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 15.05±0.40(Predicted)
- color
- White to off-white
- Water Solubility
- 1mg/L(30 ºC)
- CAS DataBase Reference
- 2998-57-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E888075
- Product name
- Estradiol3-[N,N-Bis(2-chloroethyl)carbamate]
- Packaging
- 50mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- E888075
- Product name
- Estradiol3-[N,N-Bis(2-chloroethyl)carbamate]
- Packaging
- 500mg
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- API0024779
- Product name
- ESTRAMUSTINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1319.47
- Updated
- 2021/12/16
- Product number
- E663
- Product name
- Estramustine
- Packaging
- 5mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- P000105936
- Product name
- Estramustine
- Purity
- 99+%
- Packaging
- 100mg
- Price
- $390
- Updated
- 2021/12/16
Estramustine Chemical Properties,Usage,Production
Uses
Antineoplastic.
Uses
Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.
Indications
Estramustine phosphate sodium (Emcyt) is a hybrid structure combining estradiol and a nitrogen mustard in a single molecule. The drug has been approved for use in prostatic carcinomas and will produce clinical remissions in one-third of patients who have failed to respond to previous estrogen therapy. The mechanism of action of estramustine is not well defined, but it does not appear to require either alkylation of DNA or the presence of estrogen receptors in tumor cells. Nonetheless, the toxicities of the drug are similar to those of estrogen therapy: breast tenderness and enlargement (gynecomastia), fluid retention, mild nausea, and an increased risk of thrombophlebitis and pulmonary embolism.The drug is not myelosuppressive.
Definition
ChEBI: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
Biological Functions
Estramustine has a low affinity for the βm tubulin isotype, which often is overexpressed in estramustineresistant prostatic neoplasms as one defense against this therapeutic intervention.
Mechanism of action
Because this anticancer agent contains a carbamylated nitrogen mustard moiety, it is most commonly classified as a DNA alkylator; however, it is now known that its primary mechanism of antineoplastic action is inhibition of mitosis.
Estramustine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Estramustine manufacturers
- Product
- Estramustine 2998-57-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05