ChemicalBook > CAS DataBase List > Estramustine

Estramustine

Product Name
Estramustine
CAS No.
2998-57-4
Chemical Name
Estramustine
Synonyms
LEO 275;Estracty;NSC89201;NSC 89201;NSC-89201;Estamustine;Estramustin;ESTRAMUSTINE;Alestramustine;Estramustine USP/EP/BP
CBNumber
CB9127416
Molecular Formula
C23H31Cl2NO3
Formula Weight
440.4
MOL File
2998-57-4.mol
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Estramustine Property

Melting point:
104-105°
alpha 
D20 +50° (in dioxane)
Boiling point:
565.8±50.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
15.05±0.40(Predicted)
color 
White to off-white
Water Solubility 
1mg/L(30 ºC)
CAS DataBase Reference
2998-57-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E888075
Product name
Estradiol3-[N,N-Bis(2-chloroethyl)carbamate]
Packaging
50mg
Price
$160
Updated
2021/12/16
TRC
Product number
E888075
Product name
Estradiol3-[N,N-Bis(2-chloroethyl)carbamate]
Packaging
500mg
Price
$1260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024779
Product name
ESTRAMUSTINE
Purity
95.00%
Packaging
1G
Price
$1319.47
Updated
2021/12/16
AK Scientific
Product number
E663
Product name
Estramustine
Packaging
5mg
Price
$35
Updated
2021/12/16
Ark Pharm
Product number
P000105936
Product name
Estramustine
Purity
99+%
Packaging
100mg
Price
$390
Updated
2021/12/16
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Estramustine Chemical Properties,Usage,Production

Uses

Antineoplastic.

Uses

Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.

Indications

Estramustine phosphate sodium (Emcyt) is a hybrid structure combining estradiol and a nitrogen mustard in a single molecule. The drug has been approved for use in prostatic carcinomas and will produce clinical remissions in one-third of patients who have failed to respond to previous estrogen therapy. The mechanism of action of estramustine is not well defined, but it does not appear to require either alkylation of DNA or the presence of estrogen receptors in tumor cells. Nonetheless, the toxicities of the drug are similar to those of estrogen therapy: breast tenderness and enlargement (gynecomastia), fluid retention, mild nausea, and an increased risk of thrombophlebitis and pulmonary embolism.The drug is not myelosuppressive.

Definition

ChEBI: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.

Biological Functions

Estramustine has a low affinity for the βm tubulin isotype, which often is overexpressed in estramustineresistant prostatic neoplasms as one defense against this therapeutic intervention.

Mechanism of action

Because this anticancer agent contains a carbamylated nitrogen mustard moiety, it is most commonly classified as a DNA alkylator; however, it is now known that its primary mechanism of antineoplastic action is inhibition of mitosis.

Estramustine Preparation Products And Raw materials

Raw materials

Preparation Products

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Estramustine Suppliers

China 57 Europe 2 Germany 2 India 4 South Korea 1 United Kingdom 8 United States 16 Global 90
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View Lastest Price from Estramustine manufacturers

Dideu Industries Group Limited
Product
Estramustine 2998-57-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-05

2998-57-4, EstramustineRelated Search:

Carmustine Methanol Kresoxim-methyl Acetonitrile Bendamustine hydrochloride Basic Violet 1 Mechlorethamine hydrochloride Methylparaben Paraquat dichloride Chlorambucil Bendamustine Estradiol CHLOROPHOSPHONAZO III Methyl acrylate Methyl Estramustine sodium phosphate estramustine phosphate Chlormethine

  • 3,5(10)-triene-3,17-diol(17beta)-estra-3-(bis(2-chloroethyl)carbamate)
  • LEO 275
  • 1,3,5(10)-Estratriene-3,17β-diol 3-[bis(2-chloroethyl)carbamate]
  • 1,3,5(10)-Estratriene-3,17β-diol 3-[N,N-bis(2-chloroethyl)carbamate]
  • Estamustine
  • estradiol,3-(bis(2-chloroethyl)carbamate)
  • ESTRAMUSTINE
  • Estramustin
  • Estra-1,3,5(10)-triene-3,17-diol (17b)-, 3-[bis(2-chloroethyl)carbamate]
  • Estra-1,3,5(10)-triene-3,17-diol, 3-(bis(2-chloroethyl)carbamate), (17 beta)-
  • Alestramustine
  • (17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) N,N-bis(2-chloroethyl)carbamate
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate)
  • Estracty
  • Estradiol 3-[N,N-bis(2-chloroethyl)carbamate]
  • Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate]
  • Estramustine USP/EP/BP
  • Estramustine Na USP/EP/BP
  • NSC 89201
  • NSC89201
  • NSC-89201
  • Microtubule/Tubulin,Estramustine,inhibit,prostate tumor,Inhibitor,antineoplastic,depolymerization,antimitotic
  • 2998-57-4
  • C23H31Cl2NO3NaO3P
  • C23H31Cl2NO3