Estradiol
- Product Name
- Estradiol
- CAS No.
- 57-91-0
- Chemical Name
- Estradiol
- Synonyms
- α-Estradiol;BETA-ESTRADIOL;B-ESTRADIOL;ALPHA-ESTRADIOL;17B-ESTRADIOL;Alfatradiol;17α-estradiol;17A-ESTRADIOL;17ALPHA-ESTRADIOL;Estradiol EP Impurity B
- CBNumber
- CB7289534
- Molecular Formula
- C18H24O2
- Formula Weight
- 272.39
- MOL File
- 57-91-0.mol
Estradiol Property
- Melting point:
- 176-180 °C(lit.)
- alpha
- D20 +53 to +56° (c = 0.9 in dioxane)
- Boiling point:
- 355.44°C (rough estimate)
- Density
- 1.0708 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- ethanol: 50 mg/mL, clear, colorless
- form
- powder
- pka
- 10.27±0.60(Predicted)
- color
- white with slight yellow
- Water Solubility
- 3.9mg/L(25 ºC)
- Merck
- 14,3704
- CAS DataBase Reference
- 57-91-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
- EPA Substance Registry System
- Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 45-48-40
- Safety Statements
- 53-45-24/25-22
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- KG3750000
- F
- 8-10
- HS Code
- 29372390
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H362May cause harm to breast-fed children
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P273Avoid release to the environment.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E8750
- Product name
- α-Estradiol
- Purity
- powder, ≥98% (TLC)
- Packaging
- 1g
- Price
- $449.4
- Updated
- 2024/03/01
- Product number
- 46542
- Product name
- α-Estradiol
- Purity
- VETRANAL
- Packaging
- 100mg
- Price
- $156
- Updated
- 2024/03/01
- Product number
- 20776
- Product name
- 17α-Estradiol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 20776
- Product name
- 17α-Estradiol
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- E8750
- Product name
- α-Estradiol
- Purity
- powder, ≥98% (TLC)
- Packaging
- 100mg
- Price
- $120
- Updated
- 2024/03/01
Estradiol Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
target
Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor
storage
Room temperature
Purification Methods
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
Estradiol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Estradiol manufacturers
- Product
- 17a-estradiol 57-91-0
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2023-10-12
- Product
- Estradiol 57-91-0
- Price
- US $9.90/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-05-17
- Product
- Estradiol 57-91-0
- Price
- US $3.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10 tons
- Release date
- 2024-03-27