EPIMESTROL
- Product Name
- EPIMESTROL
- CAS No.
- 7004-98-0
- Chemical Name
- EPIMESTROL
- Synonyms
- Org 817;Stimovul;NSC 55975;EPIMESTROL;Estriol Impurity 11;3-Methoxy-17-epiestriol;3-Methoxyestra-1,3,5(10)-triene-16.α.,17.α.-diol;3-Methoxy)estra-1,3,5(10)-triene-16alpha,17alpha-diol;Estra-1,3,5(10)-triene-16,17-diol, 3-methoxy-, (16α,17α)-;(8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
- CBNumber
- CB5363814
- Molecular Formula
- C19H26O3
- Formula Weight
- 302.41
- MOL File
- 7004-98-0.mol
EPIMESTROL Property
- Melting point:
- 158-160°
- alpha
- D20 +48° (chloroform)
- Boiling point:
- 450.8±45.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- pka
- 14.53±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- SHG0004891
- Product name
- EPIMESTROL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.44
- Updated
- 2021/12/16
EPIMESTROL Chemical Properties,Usage,Production
Originator
Stimovul,Organon,W. Germany,1976
Uses
Anterior pituitary activator.
Definition
ChEBI: Epimestrol is a steroid. It derives from a hydride of an estrane.
Manufacturing Process
Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17- dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully maintained at 40°C (water bath), and 200 g of freshly prepared sodium amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and at this point an additional 100 cc of 50% acetic acid were added. After all the reducing agent had been added, the mixture was transferred to a separatory funnel with ether and water. The mercury plus aqueous phase was separated, after partitioning, from the ether; the latter may be further washed with water, with 0.5N sodium hydroxide, and again with water to purify the alpha glycol. Evaporation of the ethereal phase yielded a crystalline residue of the isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid 16(α),17(α)dihydroxy-steroid-3-methyl ether.
Therapeutic Function
Anterior pituitary activator
EPIMESTROL Preparation Products And Raw materials
Raw materials
Preparation Products
EPIMESTROL Suppliers
- Tel
- 021-20221225 13917446399
- Fax
- QQ:115820162
- sales@zhiwe.net
- Country
- China
- ProdList
- 588
- Advantage
- 61
- Tel
- 029-63373950 15353716720
- 1052@dideu.com
- Country
- China
- ProdList
- 10008
- Advantage
- 58
- Tel
- 18162595016
- 3287908757@qq.com
- Country
- China
- ProdList
- 9887
- Advantage
- 58