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EPIMESTROL

Product Name
EPIMESTROL
CAS No.
7004-98-0
Chemical Name
EPIMESTROL
Synonyms
Org 817;Stimovul;NSC 55975;EPIMESTROL;Estriol Impurity 11;3-Methoxy-17-epiestriol;3-Methoxyestra-1,3,5(10)-triene-16.α.,17.α.-diol;3-Methoxy)estra-1,3,5(10)-triene-16alpha,17alpha-diol;Estra-1,3,5(10)-triene-16,17-diol, 3-methoxy-, (16α,17α)-;(8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
CBNumber
CB5363814
Molecular Formula
C19H26O3
Formula Weight
302.41
MOL File
7004-98-0.mol
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EPIMESTROL Property

Melting point:
158-160°
alpha 
D20 +48° (chloroform)
Boiling point:
450.8±45.0 °C(Predicted)
Density 
1.185±0.06 g/cm3(Predicted)
pka
14.53±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
SHG0004891
Product name
EPIMESTROL
Purity
95.00%
Packaging
5MG
Price
$495.44
Updated
2021/12/16
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EPIMESTROL Chemical Properties,Usage,Production

Originator

Stimovul,Organon,W. Germany,1976

Uses

Anterior pituitary activator.

Definition

ChEBI: Epimestrol is a steroid. It derives from a hydride of an estrane.

Manufacturing Process

Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17- dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully maintained at 40°C (water bath), and 200 g of freshly prepared sodium amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and at this point an additional 100 cc of 50% acetic acid were added. After all the reducing agent had been added, the mixture was transferred to a separatory funnel with ether and water. The mercury plus aqueous phase was separated, after partitioning, from the ether; the latter may be further washed with water, with 0.5N sodium hydroxide, and again with water to purify the alpha glycol. Evaporation of the ethereal phase yielded a crystalline residue of the isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid 16(α),17(α)dihydroxy-steroid-3-methyl ether.

Therapeutic Function

Anterior pituitary activator

EPIMESTROL Preparation Products And Raw materials

Raw materials

Preparation Products

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EPIMESTROL Suppliers

Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
Advantage
58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
9122
Advantage
58

7004-98-0, EPIMESTROLRelated Search:


  • EPIMESTROL
  • Stimovul
  • Org 817
  • NSC 55975
  • 3-Methoxy-17-epiestriol
  • 3-Methoxy)estra-1,3,5(10)-triene-16alpha,17alpha-diol
  • Estriol Impurity 11
  • 3-Methoxyestra-1,3,5(10)-triene-16.α.,17.α.-diol
  • (8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
  • Estra-1,3,5(10)-triene-16,17-diol, 3-methoxy-, (16α,17α)-
  • 7004-98-0