Estradiol

ChemicalBook > CAS DataBase List > Estradiol

Product Name: Estradiol
CAS No.: 57-91-0
Chemical Name: Estradiol
Synonyms: α-Estradiol;BETA-ESTRADIOL;B-ESTRADIOL;ALPHA-ESTRADIOL;17B-ESTRADIOL;Alfatradiol;17α-estradiol;17A-ESTRADIOL;17ALPHA-ESTRADIOL;Estradiol EP Impurity B
CBNumber: CB7289534
Molecular Formula: C18H24O2
Formula Weight: 272.39
MOL File: 57-91-0.mol

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Estradiol Property

Melting point:: 176-180 °C(lit.)
alpha: D20 +53 to +56° (c = 0.9 in dioxane)
Boiling point:: 355.44°C (rough estimate)
Density: 1.0708 (rough estimate)
refractive index: 1.4800 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: ethanol: 50 mg/mL, clear, colorless
form: powder
pka: 10.27±0.60(Predicted)
color: white with slight yellow
Water Solubility: 3.9mg/L(25 ºC)
Merck: 14,3704
CAS DataBase Reference: 57-91-0(CAS DataBase Reference)
NIST Chemistry Reference: Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA Substance Registry System: Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

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Safety

Hazard Codes: T,Xn
Risk Statements: 45-48-40
Safety Statements: 53-45-24/25-22
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: KG3750000
F: 8-10
HS Code: 29372390

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H362May cause harm to breast-fed children

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E8750
Product name: α-Estradiol
Purity: powder, ≥98% (TLC)
Packaging: 1g
Price: $449.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46542
Product name: α-Estradiol
Purity: VETRANAL
Packaging: 100mg
Price: $156
Updated: 2024/03/01

Cayman Chemical

Product number: 20776
Product name: 17α-Estradiol
Purity: ≥98%
Packaging: 50mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 20776
Product name: 17α-Estradiol
Purity: ≥98%
Packaging: 100mg
Price: $76
Updated: 2024/03/01

Sigma-Aldrich

Product number: E8750
Product name: α-Estradiol
Purity: powder, ≥98% (TLC)
Packaging: 100mg
Price: $120
Updated: 2024/03/01

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Estradiol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Definition

ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).

Biological Activity

Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

target

storage

Room temperature

Purification Methods

17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Estradiol Preparation Products And Raw materials

Raw materials

Preparation Products

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Estradiol Suppliers

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View Lastest Price from Estradiol manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: Estradiol 57-91-0
Price: US $9.90/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-05-17

Hong Kong Excellence Biotechnology Co., Ltd.

Product: 17a-estradiol 57-91-0
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20tons
Release date: 2023-10-12

Shanghai Aosiris new Material Technology Co., LTD

Product: Estradiol 57-91-0
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-03-27

57-91-0, EstradiolRelated Search:

BETA-ESTRADIOL 3-BENZOATE,BETA-ESTRADIOL BENZOATE,B-ESTRADIOL-3-BENZOATE BETA-ESTRADIOL 17-VALERATE EPIMESTROL Inositol Estradiol Cypionate Acid Red 94 Quinestrol β-Estradiol Ethynyl estradiol ESTRADIOL 17-HEPTANOATE,BETA-ESTRADIOL-17-ENANTHATE 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 2-METHYL ETHER 3-ACETATE 17-ETHYLENEKETAL (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol Oracon 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER 17-ETHYLENEKETAL 17-EPIESTRIOL 17ALPHA-ESTRADIOL-2,4-D2 BETA-ESTRADIOL 3-METHYL ETHER DELTA-9(11)-ESTRADIOL

1,3,5-estratriene-3,17-alpha-diol

1,3,5-Estratriene-3,17alpha-diol

17alpha-Oestradiol

3,17alpha-Dihydroxyestra-1,3,5(10)-triene

3,17-alpha-dihydroxyoestra-1,3,5(10)-triene

3,17alpha-Dihydroxyoestra-1,3,5(10)-triene

5(10)-triene-3,17-diol,(17-alpha)-estra-3

epiestradial

Estra-1,3,5(10)-triene-3,17alpha-diol

Estra-1,3,5(10)-triene-3,17-diol, (17alpha)-

Estradiol, 17alpha-

Oestra-1,3,5(10)-triene-3,17alpha-diol

Oestradiol-17alpha

oestradiol-17-alpha

Ethinylestradiol Impurity 12（Ethinylestradiol EP Impurity L）

1,3,5(10)-estratriene-3,17α-diol

A-ESTRADIOL

(8S,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta

17A-ESTRADIOL-CARC USP28

1,3,5-Estratriene-3,17β-diol, 3,17β-Dihydroxy-1,3,5(10)-estratriene

C02537

α-Estradiol,1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol

13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol

17-Epiestradiol

17α-Oestradiol

3,17α-Dihydroxyoestra-1,3,5(10)-triene

Alfatradiol

Epiestrol

IMp. L (EP): Estra-1,3,5(10)-triene-3,17a-diol (17a-Estradiol

ESTRADIOL, 17a-(P)

17-epi-Estradiol (Estradiol IMpurity B)

Epiestradiol 17a-Estradiol

17a-Estradiol solution,100ppm

(8R,9S,13S,14S,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Estradiol Impurity 2(Estradiol EP Impurity B)

3-O-Methyl-6-oxo 17&beta

4-Methyl-17&alpha

2-Methoxy-d3 17&beta

α-Estradiol 57-91-0

7Α-Estriol

17-O-Acetyl-3-O-methyl-6-oxo 17&beta

2-Bromo 17&beta

4-Methoxy 17&beta

Estradiol EP Impurity B

2-Hydroxy-17&beta

4-Carboxyl-17&beta

4-Formyl-17&beta

3-O-Methyl 17&alpha

4-Bromo 17&beta

(4-Methyl-d3)-17&alpha

4-Hydroxy-17&beta

2-Formyl-17&beta

B-ESTRADIOL

BETA-ESTRADIOL

CIS-ESTRADIOL

EPIESTRADIOL

E 2

DIOGYN