ChemicalBook > CAS DataBase List > 5-Aminoisoindolin-1-one

5-Aminoisoindolin-1-one

Product Name
5-Aminoisoindolin-1-one
CAS No.
222036-66-0
Chemical Name
5-Aminoisoindolin-1-one
Synonyms
5-aminoisoindolin-1-one;5-aMinoisoindoline-1-one;5-aMino-2,3-dihydro- Isoindol-1-one;5-amino-2,3-dihydro-1H-Isoindol-1-one;1H-Isoindol-1-one, 5-amino-2,3-dihydro;5-Aminoisoindolin-1-one ISO 9001：2015 REACH;1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)
CBNumber
CB21276060
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
222036-66-0.mol
More
Less

5-Aminoisoindolin-1-one Property

Melting point:
197-199 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
520.0±50.0 °C(Predicted)
Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
15.12±0.20(Predicted)
color 
Yellow
InChI
InChI=1S/C8H8N2O/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4,9H2,(H,10,11)
InChIKey
RGJCJWXNNDARPQ-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(N)C=C2)CN1
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A611590
Product name
5-Aminoisoindolin-1-one
Packaging
100mg
Price
$165
Updated
2021/12/16
Oakwood
Product number
077850
Product name
5-Amino-2,3-dihydro-1H-isoindol-1-one
Purity
98%
Packaging
250mg
Price
$35
Updated
2021/12/16
AK Scientific
Product number
W4579
Product name
5-Aminoisoindolin-1-one
Packaging
5g
Price
$331
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-21
Product name
5-Amino-2,3-dihydro- isoindol-1-one
Purity
98%
Packaging
1g
Price
$445
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0117386
Product name
5-AMINOISOINDOLIN-1-ONE
Purity
95.00%
Packaging
100MG
Price
$750.75
Updated
2021/12/16
More
Less

5-Aminoisoindolin-1-one Chemical Properties,Usage,Production

Uses

5-Aminoisoindolin-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.

Synthesis

110568-64-4

222036-66-0

General procedure for the synthesis of 5-amino-2,3-dihydroisoindol-1-one from 6-nitro-isoindolin-1-one: A mixture of 6-nitro-isoindolin-1-one (100 mg, 0.56 mmol), and reduced iron powder (314 mg, 5.6 mmol) was added to ethanol (2.0 mL) and concentrated hydrochloric acid (0.5 mL) and heated and refluxed for 2 hours. The completion of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, it was cooled to room temperature, the acid in the reaction solution was neutralized with a methanol solution saturated with ammonia (NH3), filtered through diatomaceous earth, the filtrates were washed with methanol, the filtrates were combined and the solvent was evaporated under reduced pressure to give 5-amino-2,3-dihydroisoindol-1-one (70.0 mg, 84% yield) as a white solid.

References

[1] Patent: CN103804358, 2016, B. Location in patent: Paragraph 0126
[2] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 287
[4] Patent: WO2006/17443, 2006, A2. Location in patent: Page/Page column 154-155
[5] Patent: US2010/15141, 2010, A1. Location in patent: Page/Page column 26

5-Aminoisoindolin-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Aminoisoindolin-1-one Suppliers

Canada 1 China 99 Europe 1 Germany 1 India 3 Switzerland 1 United Kingdom 1 United States 7 Global 114
QINGDAO CARELONGPHARMATECH CO.,LTD
Tel
0532-0532-88191853 13061484198
Fax
+86-532-88191853
Email
sales@carelongchem.com
Country
China
ProdList
439
Advantage
57
Shanghai Anmike Chemical Co. Ltd.
Tel
微信 17321281695 18019252918
Fax
021-31261685
Email
sale@amkchem.com
Country
China
ProdList
9405
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
EnciPharmatech Co., Ltd
Tel
025-52714267-66 13813902930
Fax
86 025 52714266
Email
stephen_shengll@hotmail.com
Country
China
ProdList
232
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Shanghai yirong biology science and technology co., ltd
Tel
18049974220
Fax
+86 (21) 51062076
Email
3060526242@qq.com
Country
China
ProdList
995
Advantage
60
Dtchem Laboratories,（Gan Su）Co.,Ltd.
Tel
18993966060
Fax
0943-8288977
Email
sales@techbiochem.com
Country
China
ProdList
806
Advantage
61
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1618
Advantage
59
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3731
Advantage
55
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.
Tel
0515-89701588 13770166955
Fax
0515-87400189
Email
orgunion@orgunion.com
Country
China
ProdList
620
Advantage
55
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2647
Advantage
55
Shanghai Leto Pharmatech Co.,Ltd.
Tel
18016401466
Fax
QQ: 1375988926
Email
sales@letopharm.com
Country
China
ProdList
245
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Beijing Wuyunyongchang Science and Technology Co., Ltd.
Tel
15210642910
Email
moon5.1days@126.com
Country
China
ProdList
202
Advantage
56
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.
Tel
02161555100
Fax
-
Country
China
ProdList
820
Advantage
58
Jinan Ruixing Pharmaceutical technology Co., Ltd.
Tel
531-88883606 15688880361
Fax
+86-531-69950228 QQ839101288 QQ2793626495
Email
sales@jnrxchem.com
Country
China
ProdList
111
Advantage
55
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Shanghai Chenzhu Pharmaceutical Co., Ltd.
Tel
13162380607
Fax
QQ:1696175688
Email
1696175688@qq.com
Country
China
ProdList
817
Advantage
55
Shanghai Qing Cang Chemical Technology Co., Ltd.
Tel
00000000000
Fax
-
Email
sales@qingcangchem.com
Country
China
ProdList
509
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Huaxing Biological Technology Co., Ltd.
Tel
18621295758
Fax
-QQ:1449085402
Email
1449085402@qq.com
Country
China
ProdList
1951
Advantage
55
Sichuan BaiPeng Biotechnology Co., Ltd.
Tel
028-65791793 18140026355
Fax
QQ568470422
Email
568470422@qq.com
Country
China
ProdList
9997
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Henan Aosman Biotechnology Co., LTD
Tel
0371-0371-61318675 17719817155
Fax
0371-61318675
Email
sales@xlinebio.com
Country
China
ProdList
2857
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10083
Advantage
58
More
Less

View Lastest Price from 5-Aminoisoindolin-1-one manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-Isoindol-1-one, 5-amino-2,3-dihydro 222036-66-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-Isoindol-1-one, 5-amino-2,3-dihydro 222036-66-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
5-Aminoisoindolin-1-one 222036-66-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

222036-66-0, 5-Aminoisoindolin-1-oneRelated Search:

4-Chloro-5-nitrophthalimide 4-Aminophthalimide 4-Nitro-N-methylphthalimide 4-Nitrophthalimide 5-AMINO-2-(2-HYDROXY-ETHYL)-ISOINDOLE-1,3-DIONE 4,5-DIANILINOPHTHALIMIDE N-CHLOROMETHYL-4-NITROPHTHALIMIDE 4-AMINO-N-METHYLPHTHALIMIDE 4-NITRO-N-PHENYLPHTHALIMIDE 5-AMINO-2-P-TOLYL-ISOINDOLE-1,3-DIONE (5-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ACETIC ACID 4-(5-AMINO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID METHYL ESTER 4-(5-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID 5-AMINO-2-NAPHTHALEN-2-YL-ISOINDOLE-1,3-DIONE 5-(ethylamino)-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione 5-AMINO-2-NAPHTHALEN-1-YL-ISOINDOLE-1,3-DIONE 5-amino-2-(propan-2-yl)-2,3-dihydro-1H-isoindole-1,3-dione N-(O-NITROPHENYL)4-NITROPHTHALIMIDE

  • 1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)
  • 5-amino-2,3-dihydro-1H-Isoindol-1-one
  • 5-aminoisoindolin-1-one
  • 1H-Isoindol-1-one, 5-amino-2,3-dihydro
  • 5-aMino-2,3-dihydro- Isoindol-1-one
  • 5-aMinoisoindoline-1-one
  • 5-Aminoisoindolin-1-one ISO 9001：2015 REACH
  • 222036-66-0
  • Quinolines
  • AMINEPRIMARY