1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)
- Product Name
- 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)
- CAS No.
- 673487-32-6
- Chemical Name
- 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)
- Synonyms
- 4-Methylbenzimidazole-2-carboxylic Acid;4-Methyl-1H-benzimidazole-2-carboxylic acid;7-Methyl-1H-BenziMidazole-2-carboxylic Acid;4-Methyl-1H-benzoimidazole-2-carboxylic acid;1H-Benzimidazole-2-carboxylic acid, 7-methyl-;4-Methyl-1H-1,3-benzodiazole-2-carboxylic acid;4-Methyl-1H-benzo[d]iMidazole-2-carboxylic acid;7-methyl-1H-benzo[d]imidazole-2-carboxylic acid;1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI);4-Methyl-1H-benzoimidazole-2-carboxylic acid, CAS 673487-32-6
- CBNumber
- CB21292866
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 673487-32-6.mol
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Property
- Boiling point:
- 444.5±38.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 1.53±0.30(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M643290
- Product name
- 4-methyl-1H-benzimidazole-2-carboxylicacid
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR951085
- Product name
- 4-Methyl-1H-benzimidazole-2-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 073299
- Product name
- 4-Methyl-1H-benzimidazole-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- OR951085
- Product name
- 4-Methyl-1H-benzimidazole-2-carboxylicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $665
- Updated
- 2021/12/16
- Product number
- W7786
- Product name
- 4-Methyl-1H-benzimidazole-2-carboxylicacid
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Chemical Properties,Usage,Production
Synthesis
191794-20-4
673487-32-6
General procedure for the synthesis of 4-methyl-1H benzimidazole-2-carboxylic acid from (7-methyl-1H-benzo[d]imidazol-2-yl)methanol: To a suspension of (4-methyl-1H-benzoimidazol-2-yl)methanol (0.84 g, 5.18 mmol) in water (10 mL) was added 2M Na2CO3 solution (10 mL). To the mixture was slowly added 0.1 M KMnO4 solution (1.4 g, 8.8 mmol) dropwise. The reaction mixture was heated to 100 °C and kept for 2 h. After completion of the reaction, it was filtered while hot. The filtrate was cooled and acidified with 3N acetic acid. The resulting solid was collected by filtration, washed with water and dried under vacuum to afford the crude 4-methyl-1H-benzimidazole-2-carboxylic acid (0.56 g, 62% yield), which could be used for the next reaction without further purification. The above carboxylic acid (111.6 mg, 0.63 mmol) was suspended in DMF (3 mL), CDI (108.9 mg, 0.67 mmol) was added and the mixture was stirred for 1 hour. Subsequently, methylpiperazine (80 μL) was added and the reaction mixture continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was poured into water (50 mL) and extracted with dichloromethane. The organic phases were combined, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (silica gel 10 g; eluent: 1-8% methanol (containing 2M NH3)/dichloromethane) to give 124.3 mg of white solid product (76% yield). The mass spectrum and 1H NMR data were consistent with the target product.
References
[1] Patent: WO2004/22060, 2004, A2. Location in patent: Page/Page column 33-34
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) manufacturers
- Product
- 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) 673487-32-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13