ChemicalBook > CAS DataBase List > 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)

1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)

Product Name
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)
CAS No.
673487-32-6
Chemical Name
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)
Synonyms
4-Methylbenzimidazole-2-carboxylic Acid;4-Methyl-1H-benzimidazole-2-carboxylic acid;7-Methyl-1H-BenziMidazole-2-carboxylic Acid;4-Methyl-1H-benzoimidazole-2-carboxylic acid;1H-Benzimidazole-2-carboxylic acid, 7-methyl-;4-Methyl-1H-1,3-benzodiazole-2-carboxylic acid;4-Methyl-1H-benzo[d]iMidazole-2-carboxylic acid;7-methyl-1H-benzo[d]imidazole-2-carboxylic acid;1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI);4-Methyl-1H-benzoimidazole-2-carboxylic acid, CAS 673487-32-6
CBNumber
CB21292866
Molecular Formula
C9H8N2O2
Formula Weight
176.17
MOL File
673487-32-6.mol
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1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Property

Boiling point:
444.5±38.0 °C(Predicted)
Density 
1.421±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
pka
1.53±0.30(Predicted)
Appearance
White to yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
M643290
Product name
4-methyl-1H-benzimidazole-2-carboxylicacid
Packaging
50mg
Price
$90
Updated
2021/12/16
Apolloscientific
Product number
OR951085
Product name
4-Methyl-1H-benzimidazole-2-carboxylicacid
Purity
95%
Packaging
250mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
W7786
Product name
4-Methyl-1H-benzimidazole-2-carboxylicacid
Packaging
1g
Price
$186
Updated
2021/12/16
Apolloscientific
Product number
OR951085
Product name
4-Methyl-1H-benzimidazole-2-carboxylicacid
Purity
95%
Packaging
1g
Price
$225
Updated
2021/12/16
Matrix Scientific
Product number
073299
Product name
4-Methyl-1H-benzimidazole-2-carboxylic acid
Purity
95+%
Packaging
250mg
Price
$260
Updated
2021/12/16
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1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Chemical Properties,Usage,Production

Synthesis

191794-20-4

673487-32-6

General procedure for the synthesis of 4-methyl-1H benzimidazole-2-carboxylic acid from (7-methyl-1H-benzo[d]imidazol-2-yl)methanol: To a suspension of (4-methyl-1H-benzoimidazol-2-yl)methanol (0.84 g, 5.18 mmol) in water (10 mL) was added 2M Na2CO3 solution (10 mL). To the mixture was slowly added 0.1 M KMnO4 solution (1.4 g, 8.8 mmol) dropwise. The reaction mixture was heated to 100 °C and kept for 2 h. After completion of the reaction, it was filtered while hot. The filtrate was cooled and acidified with 3N acetic acid. The resulting solid was collected by filtration, washed with water and dried under vacuum to afford the crude 4-methyl-1H-benzimidazole-2-carboxylic acid (0.56 g, 62% yield), which could be used for the next reaction without further purification. The above carboxylic acid (111.6 mg, 0.63 mmol) was suspended in DMF (3 mL), CDI (108.9 mg, 0.67 mmol) was added and the mixture was stirred for 1 hour. Subsequently, methylpiperazine (80 μL) was added and the reaction mixture continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was poured into water (50 mL) and extracted with dichloromethane. The organic phases were combined, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (silica gel 10 g; eluent: 1-8% methanol (containing 2M NH3)/dichloromethane) to give 124.3 mg of white solid product (76% yield). The mass spectrum and 1H NMR data were consistent with the target product.

References

[1] Patent: WO2004/22060, 2004, A2. Location in patent: Page/Page column 33-34

1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) manufacturers

Career Henan Chemical Co
Product
1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI) 673487-32-6
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

673487-32-6, 1H-Benzimidazole-2-carboxylicacid,4-methyl-(9CI)Related Search:

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