5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE

Product Name: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
CAS No.: 184241-44-9
Chemical Name: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
Synonyms: NBI27914HCl;NBI 27914 hydrochlor;NBI 27914 >=98% (HPLC);NBI 27914 HYDROCHLORIDE;4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-;5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride;5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
CBNumber: CB2130693
Molecular Formula: C18H20Cl4N4
Formula Weight: 434.19
MOL File: 184241-44-9.mol

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5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Property

Boiling point:: 483.7±45.0 °C(Predicted)
Density: 1.417±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 16 mg/mL at 60 °C, soluble
form: solid
pka: 3.58±0.50(Predicted)
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N3911
Product name: NBI 27914
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $112.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: N3911
Product name: NBI 27914
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $691
Updated: 2022/05/15

Tocris

Product number: 1591
Product name: NBI27914hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 1591
Product name: NBI27914hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $724
Updated: 2021/12/16

Usbiological

Product number: 255950
Product name: NBI 27914 hydrochloride
Packaging: 10mg
Price: $423
Updated: 2021/12/16

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5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:

to study its effects on steroidogenic gene expression in GD15 mouse testis
to study its effects on amyloid β production
to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Definition

ChEBI: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine is a dialkylarylamine and a tertiary amino compound.

Biological Activity

Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo .

Biochem/physiol Actions

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Suppliers

China 8 Germany 2 Switzerland 1 United Kingdom 1 United States 4 Global 16

Tocris Bioscience

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184241-44-9, 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDERelated Search:

pyrimidine-4,6-diamine hydrochloride 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE

5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE

NBI 27914 HYDROCHLORIDE

5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride

NBI27914HCl

NBI 27914 >=98% (HPLC)

NBI 27914 hydrochlor

4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-

184241-44-9

C18H20Cl4N4

C18H20Cl4N4HCl

CRF receptor and related