ChemicalBook > CAS DataBase List > N(4)-hydroxycytidine

N(4)-hydroxycytidine

Product Name
N(4)-hydroxycytidine
CAS No.
3258-02-4
Chemical Name
N(4)-hydroxycytidine
Synonyms
EIDD-1931;N-Hydroxycytidine;0/4/58;EIDD-193;Uridine, 4-oxime;Monovir impurity A;EIDD 2801-metabolit;EIDD2801-metabolite;N(4)-hydroxycytidine;EIDD-2801-metabolite
CBNumber
CB21312265
Molecular Formula
C9H13N3O6
Formula Weight
259.22
MOL File
3258-02-4.mol
More
Less

N(4)-hydroxycytidine Property

Melting point:
169-172 °C(Solv: methanol (67-56-1))
Density 
1.93±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).
pka
8.19±0.20(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2872
Product name
EIDD-1931
Purity
≥98% (HPLC)
Packaging
5MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2872
Product name
EIDD-1931
Purity
≥98% (HPLC)
Packaging
25MG
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
5mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
9002958
Product name
EIDD-1931
Packaging
10mg
Price
$155
Updated
2024/03/01
More
Less

N(4)-hydroxycytidine Chemical Properties,Usage,Production

Description

EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.

Uses

EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses.

Definition

ChEBI: N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as a drug metabolite, a human xenobiotic metabolite, an anticoronaviral agent and an antiviral agent. It is a nucleoside analogue and a ketoxime. It is functionally related to a cytidine.

storage

Store at -20°C

References

1) Janion and Glickman (1980),?N4-hydroxycytidine: a mutagen specific for AT to GC transitions;?Mutat. Res.,?72?43 2) Stuyver?et al.?(2003),?Ribonucleotide analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture; Antimicrob. Agents Chemother.,?47?244 3) Costantini?et al.?(2012),?Antiviral activity of nucleoside analogues against norovirus; Antivir. Ther.,?17?981 4) Reynard?et al.?(2015),?Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication; Viruses,?7?6233 5) Ehteshami?et al.?(2017),?Characterization of ?-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus; Antimicrob. Agents Chemother.,?61?e02395-16 6) Yoon?et al.?(2018),?Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses; Antimicrob. Agents Chemother.,?62?e00766-18 7) Barnard?et al.?(2004),?Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine; Antivir. Chem. Chemother., 15 15 8) Pyrc et al. (2006),?Inhibition of human coronavirus NL63 infection at early stages of the replication cycle; Antimicrob. Agents Chemother.,?50?2000 9) Toots et al. (2019),?Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia; Sci. Transl. Med.,?11?eaax5866

N(4)-hydroxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N(4)-hydroxycytidine Suppliers

InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
More
Less

View Lastest Price from N(4)-hydroxycytidine manufacturers

Shanghai Biolang Biotechnology Co., Ltd.
Product
N(4)-hydroxycytidine 3258-02-4
Price
US $9.90-8.80/g
Min. Order
10g
Purity
99.99%HPLC.USP42
Supply Ability
1000kgs
Release date
2022-02-10

3258-02-4, N(4)-hydroxycytidineRelated Search:


  • N(4)-hydroxycytidine
  • 1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one
  • 3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one
  • N-Hydroxycytidine
  • β-D-N4-Hydroxycytidine
  • Beta-d-N4-hydroxycytidine
  • EIDD-1931
  • Beta-d-N4-hydroxycytidine (NHC)
  • Uridine, 4-oxime
  • EIDD2801 ,β-D-N4-hydroxycytidine
  • EIDD-193
  • Molnupiravir Impurity 1
  • Molnupiravir Impurity A/N-hydroxycytidine
  • 0/4/58
  • EIDD-1931 (Beta-d-N4-hydroxycytidine
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-oneQ: What is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the CAS Number of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the storage condition of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg
  • Chikungunya,equine,Enterovirus,HEV,EIDD 1931,HRV,Hepatitis C virus,Inhibitor,EIDD1931,CHIKV,Topoisomerase,Enterovirus,VEEV,HEVs,NHC,Rhinovirus,HCV,encephalitis,SARS-CoV,EIDD-1931,inhibit,venezuelan,HRVs,SARS coronavirus
  • 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-4-(Hydroxyamino)Pyrimidin-2-One
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one (Molnupiravir Impurity)
  • Monovir impurity A
  • N4-Hydroxycytidine (NHC)
  • EIDD 2801-metabolit
  • EIDD-2801-metabolite
  • EIDD2801-metabolite
  • 13C,15N3]-2'-Deoxycytidine
  • 3258-02-4
  • 328-02-4