ascofuranone
- Product Name
- ascofuranone
- CAS No.
- 38462-04-3
- Chemical Name
- ascofuranone
- Synonyms
- Ascofuranon;Ascofranone;ascofuranone;(-)-Ascofuranone;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde;2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]-
- CBNumber
- CB21312674
- Molecular Formula
- C23H29ClO5
- Formula Weight
- 420.93
- MOL File
- 38462-04-3.mol
ascofuranone Property
- Melting point:
- 84 °C
- Boiling point:
- 581.2±50.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- pka
- 6.32±0.50(Predicted)
- color
- Needles from Me2CO/hexane
Safety
- Toxicity
- LD50 ipr-rat: 1350 mg/kg JANTAJ 26,681,73
N-Bromosuccinimide Price
- Product number
- A787035
- Product name
- (-)-Ascofuranone
- Packaging
- 1mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- A787035
- Product name
- (-)-Ascofuranone
- Packaging
- 2.5mg
- Price
- $1590
- Updated
- 2021/12/16
- Product number
- API0016108
- Product name
- ASCOFURANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.36
- Updated
- 2021/12/16
ascofuranone Chemical Properties,Usage,Production
Uses
(-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice.
Definition
ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-).
Safety Profile
Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-.
ascofuranone Preparation Products And Raw materials
Raw materials
Preparation Products
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