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ascofuranone

Product Name
ascofuranone
CAS No.
38462-04-3
Chemical Name
ascofuranone
Synonyms
Ascofuranon;Ascofranone;ascofuranone;(-)-Ascofuranone;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde;2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]-
CBNumber
CB21312674
Molecular Formula
C23H29ClO5
Formula Weight
420.93
MOL File
38462-04-3.mol
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ascofuranone Property

Melting point:
84 °C
Boiling point:
581.2±50.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
pka
6.32±0.50(Predicted)
color 
Needles from Me2CO/hexane
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Safety

Toxicity
LD50 ipr-rat: 1350 mg/kg JANTAJ 26,681,73
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A787035
Product name
(-)-Ascofuranone
Packaging
1mg
Price
$680
Updated
2021/12/16
TRC
Product number
A787035
Product name
(-)-Ascofuranone
Packaging
2.5mg
Price
$1590
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016108
Product name
ASCOFURANONE
Purity
95.00%
Packaging
5MG
Price
$501.36
Updated
2021/12/16
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ascofuranone Chemical Properties,Usage,Production

Uses

(-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice.

Definition

ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-).

Safety Profile

Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-.

ascofuranone Preparation Products And Raw materials

Raw materials

Preparation Products

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ascofuranone Suppliers

China 4 United States 2 Global 6
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
Beijing Biocreative Technology Co., Ltd.
Tel
15522676233
Email
3007606172@qq.com
Country
China
ProdList
1248
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19704
Advantage
58

38462-04-3, ascofuranoneRelated Search:

2-Methyltetrahydrofuran-3-one trans-dimethyl-2,5-dihydrofuran-3(2H)-one Dihydrofuran-3(2H)-one OCIMENE QUINTOXIDE 2-ALLYL-6-CHLOROPHENOL ascofuranone 5-CHLORO-2-HYDROXY-3-METHYLBENZALDEHYDE

  • ascofuranone
  • 2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde
  • 3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde
  • Ascofranone
  • Ascofuranon
  • (-)-Ascofuranone
  • Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]-
  • 38462-04-3