ChemicalBook > CAS DataBase List > 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

Product Name
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
CAS No.
1977-07-7
Chemical Name
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Synonyms
Dechloroclozapine;Dopamine serotonin antagonist-1;Deschloroclozapine, 10 mM in DMSO;(4-Methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine;11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine;11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-;inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs;11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
CBNumber
CB21316359
Molecular Formula
C18H20N4
Formula Weight
292.38
MOL File
1977-07-7.mol
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Property

Boiling point:
457.5±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO : ≥ 83.3 mg/mL (284.90 mM)
pka
7.82±0.20(Predicted)
form 
solid
color 
Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
10mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
50mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0997406
Product name
11-(4-METHYL-1-PIPERAZINYL)-5H-DIBENZO(B,E)(1,4)DIAZEPINE
Purity
95.00%
Packaging
5MG
Price
$496.91
Updated
2021/12/16
ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
100mg
Price
$550
Updated
2021/12/16
Alichem
Product number
1977077
Product name
11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Packaging
100mg
Price
$780
Updated
2021/12/16
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Chemical Properties,Usage,Production

Biological Activity

Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.

Synthesis

109-01-3

5814-41-5

1977-07-7

General procedure for the synthesis of 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,E][1,4]diazepin-11-one from N-methylpiperazine and 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one: 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one (105 mg , 0.5 mmol) was placed in a 50 mL round bottom flask. N,N-dimethylaniline (36.3 mg, 0.3 mmol) was added sequentially. An appropriate amount of super-dry trichlorophosphorus and a magnetic stirrer were added and the mixture was stirred under reflux conditions for 12 h at 130°C under nitrogen protection. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation. Subsequently, the reaction was terminated by adding an appropriate amount of N-methylpiperazine and continued stirring for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was extracted with ethyl acetate (3 x 70 mL) and washed sequentially with water. The organic layers were combined and dried by adding anhydrous Na2SO4. After filtration, the residue was concentrated. Purification by column chromatography (eluent: dichloromethane/methanol = 25:1) afforded 110 mg of the target product 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,E][1,4]diazepine in 75% yield.

in vitro

Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.

b>

target

Ki: 6.3 nM (hM 3 Dq), 4.2 nM (hM 4 Di)

storage

Room temperature

References

[1] Patent: CN108586364, 2018, A. Location in patent: Paragraph 0150; 0151; 0152

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Dopamine serotonin antagonist-1 1977-07-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-23

1977-07-7, 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepineRelated Search:

Lasmiditan Impurity 7 Lasmiditan Impurity 3 LasMiditan 1-(((2S,3R)-2-(2,4-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole (1-methylpiperidin-4-yl)(pyridin-2-yl)methanone (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone Lasmiditan Impurity 5 Diacetonefructose Lasmiditan Impurity 6 (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid Lasmiditan Impurity 1

  • 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • Dopamine serotonin antagonist-1
  • Dechloroclozapine
  • 5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-
  • 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs
  • 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
  • Deschloroclozapine, 10 mM in DMSO
  • (4-Methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine
  • 1977-07-7