TAS 103

Product Name: TAS 103
CAS No.: 174634-08-3
Chemical Name: TAS 103
Synonyms: TAS 103;CS-1287;BMS-247615;TAS-103 HC1;TAS-103 base;TAS-103(salt);TA103(bms-247615);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one;7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-
CBNumber: CB21321579
Molecular Formula: C20H19N3O2
Formula Weight: 333.38
MOL File: 174634-08-3.mol

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TAS 103 Property

Melting point:: 216-217 °C(Solv: ethanol (64-17-5))
Boiling point:: 589.5±50.0 °C(Predicted)
Density: 1.350±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 7.88±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31002974
Product name: TAS-103
Purity: 98+%
Packaging: 5mg
Price: $83
Updated: 2021/12/16

Crysdot

Product number: CD31002974
Product name: TAS-103
Purity: 98+%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

Crysdot

Product number: CD31002974
Product name: TAS-103
Purity: 98+%
Packaging: 50mg
Price: $381
Updated: 2021/12/16

Crysdot

Product number: CD31002974
Product name: TAS-103
Purity: 98+%
Packaging: 100mg
Price: $658
Updated: 2021/12/16

DC Chemicals

Product number: DC7898
Product name: TAS-103(BMS247615)
Purity: >98%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

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TAS 103 Chemical Properties,Usage,Production

Uses

TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.

Biological Activity

TAS-103 is a dual DNA topoisomerase I/II (topoisomerase I/II) inhibitor for cancer research.

in vivo

TAS-103 (30 mg/kg, iv) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.

target

Topoisomerase I

Topoisomerase II

IC 50

Topoisomerase I; Topoisomerase II

References

[1] Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II DOI:10.1016/s0006-2952(00)00402-0
[2] Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7. DOI:10.1248/bpb.25.1385
[3] Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94. Epu DOI:10.1124/mol.107.043307

TAS 103 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAS 103 Suppliers

China 28 United States 4 USA 1 Global 33

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

MedChemExpress

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Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

174634-08-3, TAS 103Related Search:

TAS 103

6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one

TAS-103 HC1

TA103(bms-247615)

TAS-103 base

BMS-247615

TAS-103(salt)

CS-1287

7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-

174634-08-3