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squalamine

Product Name
squalamine
CAS No.
148717-90-2
Chemical Name
squalamine
Synonyms
MSI 1256;Squalamine, >98%;(3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate;Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-;Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
CBNumber
CB21321973
Molecular Formula
C34H65N3O5S
Formula Weight
627.96
MOL File
148717-90-2.mol
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squalamine Property

Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (159.25 mM)
form 
Solid
pka
-3.49±0.18(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4045
Product name
Squalamine
Purity
>98.0%
Packaging
1mg
Price
$600
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015537
Product name
SQUALAMINE
Purity
95.00%
Packaging
5MG
Price
$660
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS162105
Product name
Squalamine
Packaging
1mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-4045
Product name
Squalamine
Purity
>98.0%
Packaging
5mg
Price
$1140
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS162105
Product name
Squalamine
Packaging
2mg
Price
$1220
Updated
2021/12/16
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squalamine Chemical Properties,Usage,Production

Uses

Squalamine is an aminosterol broad-spectrum antibacterial drug present in shark tissue.

Definition

ChEBI: Squalamine is a bile acid.

Biological Activity

Squalamine (MSI-1256) is a compound with broad-spectrum antiviral activity.

Synthesis

Squalamine is isolated from the stomach of spiny horn shark and sea green dog shark.

in vivo

Squalamine (2 mg/kg; Intraperitoneal injection; 28 days) inhibits tumor growth in xenografted mice with breast cancer[2].
Squalamine (20 mg; Single application; 0-3 days) has a decolonizing effect on S. aureus on the skin in a mouse model[3].
Squalamine (20-120 mg/kg; Oral gavage; 5 days) restores the function of the mesenteric nervous system in PD mouse models[4].

Animal Model:Female athymic mice aged 6 weeks old bearing breast tumor xenografts[2]
Dosage:2 mg/kg
Administration:Intraperitoneal injection (i.p.); 28 days
Result:Significantly retarded the growth of tumors, but the combination with Trastuzumab (HY-P9907) was more effective.
Suppressed MCF-7/HER-2 breast xenograft-associated angiogenesis.
Animal Model:10 μL S. aureus suspension(108 cfu/mL) was applied to the female BALB/c mice skin[3]
Dosage:20 mg
Administration:Single application; 3 days
Result:Reduced S. aureus viable cells by up to 4 log after two days compared with the control.
Animal Model:PD mice models ( hSNCAA53T mice and PrP-A53T human α-syn overexpressing transgenic mice)[4]
Dosage:20, 40, 80, or 120 mg/kg
Administration:Oral gavage (i.g.); 5 days
Result:Effectively restored disordered colonic motility in PD mice models.
Increased colonic transit in PrP-A53T mice.
Reduced myenteric intrinsic primary afferent neuron excitability in hSNCAA53T mice.

squalamine Preparation Products And Raw materials

Raw materials

Chenodeoxycholic acid Dehydroepiandrosterone Fucosterol

Preparation Products

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squalamine Suppliers

China 30 India 1 United Kingdom 1 United States 5 Global 37
Artis Chemistry (Shanghai) Co. Ltd.
Tel
86-21-60936353
Fax
86-21-60936352
Country
China
ProdList
335
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
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View Lastest Price from squalamine manufacturers

RongNa Biotechnology Co.,Ltd
Product
squalamine 148717-90-2
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
1 ton
Release date
2025-08-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Squalamine 148717-90-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Squalamine 148717-90-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

148717-90-2, squalamineRelated Search:

N-(3-AMINOPROPYL)CYCLOHEXYLAMINE N-cyclodecylmethylamine squalamine

  • (3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate
  • MSI 1256
  • Squalamine, >98%
  • Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
  • Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-
  • 148717-90-2
  • C34H65N3O5S
  • C34H67N3O5S