ascamycin
- Product Name
- ascamycin
- CAS No.
- 91432-48-3
- Chemical Name
- ascamycin
- Synonyms
- ascamycin;Ascamycin, 10 mM in DMSO;2-Chloro-5'-O-[(L-alanylamino)sulfonyl]adenosine;2-Chloro-5'-O-[[(S)-2-amino-1-oxopropyl]sulfamoyl]adenosine;(+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine
- CBNumber
- CB21333662
- Formula Weight
- 0
- MOL File
- 91432-48-3.mol
N-Bromosuccinimide Price
- Product number
- API0019259
- Product name
- ASCAMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.12
- Updated
- 2021/12/16
ascamycin Chemical Properties,Usage,Production
Uses
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively[1][2][3].
Biological Activity
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. It has selective antibacterial activity against Xanthomonas bacteria, with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
in vitro
The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface.
target
MIC: 0.4 μg/mL ( Xanthomonas citri ), 12.5 μg/mL ( Xanthomonas oryzae ) and 12.5 μg/mL ( Mycobacterium phlei )
References
[1] Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2. DOI:10.7164/antibiotics.37.670
[2] Osada H, rt al. Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri. Biochem J. 1986 Jan 15;233(2):459-63. DOI:10.1042/bj2330459
[3] Zhao C, et al. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888. PLoS One. 2014 Dec 5;9(12):e114722. DOI:10.1371/journal.pone.0114722
ascamycin Preparation Products And Raw materials
Raw materials
Preparation Products
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