quinolinic acid, 2-methyl ester
- Product Name
- quinolinic acid, 2-methyl ester
- CAS No.
- 24195-07-1
- Chemical Name
- quinolinic acid, 2-methyl ester
- Synonyms
- 2-(methoxycarbonyl)nicotinic acid;QA2ME;2-Methyl quinolinate;2-carbomethoxynicotinic acid;quinolinic acid, 2-methyl ester;2-methoxycarbonyl-3-pyridinecarboxylic acid;2-Methoxycarbonylpyridine-3-carboxylic acid;2,3-Pyridinedicarboxylic acid, 2-methyl ester
- CBNumber
- CB21334528
- Molecular Formula
- C8H7NO4
- Formula Weight
- 181.15
- MOL File
- 24195-07-1.mol
quinolinic acid, 2-methyl ester Property
- Melting point:
- 54-55 °C
- Boiling point:
- 380.7±27.0 °C(Predicted)
- Density
- 1.361±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.59±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H7NO4/c1-13-8(12)6-5(7(10)11)3-2-4-9-6/h2-4H,1H3,(H,10,11)
- InChIKey
- OSSIORZYXTUXBL-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CC=C1C(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M342130
- Product name
- 2-(Methoxycarbonyl)nicotinicacid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 083395
- Product name
- 2-(Methoxycarbonyl)nicotinic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- V4622
- Product name
- 2-(Methoxycarbonyl)nicotinicacid
- Packaging
- 10g
- Price
- $811
- Updated
- 2021/12/16
- Product number
- CHM0004162
- Product name
- PYRIDINE-2,3-DICARBOXYLIC ACID-2-METHYL ESTER
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $885.31
- Updated
- 2021/12/16
- Product number
- CHM0004162
- Product name
- PYRIDINE-2,3-DICARBOXYLIC ACID-2-METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1552.32
- Updated
- 2021/12/16
quinolinic acid, 2-methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
699-98-9
24195-07-1
General procedure for the synthesis of methyl 3-carboxylic acid pyridine-2-carboxylate from methanol and 2,3-pyridinedicarboxylic anhydride: 2,3-pyridinedicarboxylic anhydride (5.0 g, 34 mmol) was dissolved in methanol (25 mL). The reaction mixture was heated to reflux for 2 hours and the solvent was subsequently removed by rotary evaporation. The resulting white solid was dissolved in ethyl acetate (25 mL) under reflux conditions and the insoluble by-products were removed by filtration. The filtrate was concentrated under reduced pressure and recrystallized from ethyl acetate to give the final methyl 3-carboxypyridine-2-carboxylate (4.5 g, 71% yield) as a white solid with a melting point of 157-159 °C.1H NMR (300 MHz, CDCl3) δ 8.84 (dd, J=1.7,5.0 Hz, 1H), 8.34 (dd, J=1.6, 7.9 Hz, 1H), 7.57 (dd, J=5.0,8.1 Hz, 1H), 4.00 (s, 3H).
References
[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 22, p. 5192 - 5196
[2] Synlett, 2006, # 12, p. 1938 - 1942
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3840 - 3853
[4] Patent: WO2017/160898, 2017, A1. Location in patent: Paragraph 00107; 00136
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 15, p. 4544 - 4567
quinolinic acid, 2-methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
quinolinic acid, 2-methyl ester Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from quinolinic acid, 2-methyl ester manufacturers
- Product
- quinolinic acid, 2-methyl ester 24195-07-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07