2,3-Pyridinedicarboxylic acid dimethyl ester

Product Name: 2,3-Pyridinedicarboxylic acid dimethyl ester
CAS No.: 605-38-9
Chemical Name: 2,3-Pyridinedicarboxylic acid dimethyl ester
Synonyms: DIMETHYL PYRIDINE-2,3-DICARBOXYLATE;DIMETHYL 2,3-PYRIDINEDICARBOXYLATE;NSC 17026;DIMETHYL QUINOLINATE;inic acid, 2,3-dimethyL;Quinolinic acid dimethyl;Dimethylpyridine dicarboxylate;QUINOLINIC ACID DIMETHYL ESTER;2-amino-5-pyrimidinecarboxamide;Dimethyl2,3-Pyridinedicarboxylate>
CBNumber: CB2726005
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 605-38-9.mol

More

Less

2,3-Pyridinedicarboxylic acid dimethyl ester Property

Melting point:: 56°C
Boiling point:: 262.3±20.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: -0.83±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C9H9NO4/c1-13-8(11)6-4-3-5-10-7(6)9(12)14-2/h3-5H,1-2H3
InChIKey: YLGIBCYHQZTFQL-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=CC=C1C(OC)=O
CAS DataBase Reference: 605-38-9(CAS DataBase Reference)
NIST Chemistry Reference: 2,3-Pyridinedicarboxylic acid, dimethyl ester(605-38-9)

More

Less

Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S288039
Product name: PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S288039
Product name: PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
Purity: AldrichCPR
Packaging: 25MG
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: P1303
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: P1303
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $136
Updated: 2025/07/31

TRC

Product number: D477770
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Packaging: 1g
Price: $120
Updated: 2021/12/16

More

Less

2,3-Pyridinedicarboxylic acid dimethyl ester Chemical Properties,Usage,Production

Uses

Dimethyl 2,3-Pyridinedicarboxylate is a reagent in the preparation of diarylcyclopentenopyridines as endothelin receptor antagonists.

Synthesis

67-56-1

89-00-9

605-38-9

2,3-Pyridinedicarboxylic acid (80 g, 0.48 mol) was dissolved in methanol (400 ml) and stirred at room temperature for 30 minutes. Concentrated sulfuric acid (94.1 g, 0.96 mol) was then added slowly dropwise for about 1 hour. The reaction mixture was heated to 60°C and the reaction was stirred overnight. After completion of the reaction, methanol was removed by distillation under reduced pressure. The concentrate was slowly poured into aqueous sodium carbonate solution during which a large amount of gas was produced. The pH was adjusted to 7-8 and extracted with dichloromethane (1000 ml × 2). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give dimethyl 2,3-pyridinedicarboxylate as a pale yellow solid (89.7 g, 99% purity, 95.8% yield).

References

[1] Patent: CN105566319, 2016, A. Location in patent: Paragraph 0185; 0186; 0187; 0188
[2] Australian Journal of Chemistry, 1984, vol. 37, # 1, p. 87 - 94
[3] Patent: EP3252059, 2017, A1. Location in patent: Paragraph 0686; 0686-0688
[4] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 397 - 404
[5] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 433 - 450

2,3-Pyridinedicarboxylic acid dimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,3-Pyridinedicarboxylic acid dimethyl ester Suppliers

Americas 1 Belgium 2 Canada 1 China 170 Europe 1 France 1 Germany 5 India 3 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 28 Global 223

Nanjing BAM Biomedical Technology Co., Ltd.

Tel: 18066080842 13952020641
Fax: 025-58912720
Email: bamd@foxmail.com
Country: China
ProdList: 759
Advantage: 55

HONEST PHARM CO.,LTD.

Tel: 0531-59840128 19353175568
Fax: QQ:3379530787
Email: zpy8217@163.com
Country: China
ProdList: 464
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

More

Less

View Lastest Price from 2,3-Pyridinedicarboxylic acid dimethyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
Price: US $1000.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 200tons
Release date: 2025-08-13

Honest Joy Holdings Limited

Product: Dimethyl pyridine-2,3-dicarboxylate 605-38-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-20

Career Henan Chemical Co

Product: 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-25

605-38-9, 2,3-Pyridinedicarboxylic acid dimethyl esterRelated Search:

Chromium picolinate 2-Picolinic acid N,N-Dimethylformamide Dimethyl fumarate Dimethyl 2,2'-azobis(2-methylpropionate) ETHANE Zinc picolinate Pyridine-2,6-dicarboxylic acid Dimethyl phthalate Dimethyl sulfate Dimethyl sulfoxide Dimethyl sulfide Dimethyl carbonate Dacthal Dimethyl sebacate Dimethyl ether Dimethyl suberate Dimethyl isophthalate

2-amino-5-pyrimidinecarboxamide

DIMETHYL PYRIDINE-2,3-DICARBOXYLATE

DIMETHYL QUINOLINATE

DIMETHYL 2,3-PYRIDINEDICARBOXYLATE

2,3-PYRIDINEDICARBOXYLIC ACID DIMETHYL ESTER

2,3-Pyridinedicarboxylic acid dimethyl ester ,Dimethyl quinolinate

2,3-Pyridinedicarboxylic acid, 2,3-dimethyl ester

NSC 17026

Pyridinedicarboxylicaciddimethylester

methylquinolinic acid, 2,3-dimethyl ester

Quinolinic acid dimethyl

Dimethylpyridine dicarboxylate

2,3-diMethyl pyridine-2,3-dicarboxylate

Dimethyl Quinolinate 2,3-Pyridinedicarboxylic Acid Dimethyl Ester Quinolinic Acid Dimethyl Ester

PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER

QUINOLINIC ACID DIMETHYL ESTER

Dimethyl2,3-Pyridinedicarboxylate&gt

inic acid, 2,3-dimethyL

2,3-Dimethyl 2,3-pyridinedicarboxylate

605-38-9

605-38-7

Heterocycle-Pyridine series