ChemicalBook > CAS DataBase List > 2,3-Pyridinedicarboxylic acid dimethyl ester
2,3-Pyridinedicarboxylic acid dimethyl ester
- Product Name
- 2,3-Pyridinedicarboxylic acid dimethyl ester
- CAS No.
- 605-38-9
- Chemical Name
- 2,3-Pyridinedicarboxylic acid dimethyl ester
- Synonyms
- DIMETHYL PYRIDINE-2,3-DICARBOXYLATE;DIMETHYL 2,3-PYRIDINEDICARBOXYLATE;NSC 17026;DIMETHYL QUINOLINATE;inic acid, 2,3-dimethyL;Quinolinic acid dimethyl;Dimethylpyridine dicarboxylate;QUINOLINIC ACID DIMETHYL ESTER;2-amino-5-pyrimidinecarboxamide;Dimethyl2,3-Pyridinedicarboxylate>
- CBNumber
- CB2726005
- Molecular Formula
- C9H9NO4
- Formula Weight
- 195.17
- MOL File
- 605-38-9.mol
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2,3-Pyridinedicarboxylic acid dimethyl ester Property
- Melting point:
- 56°C
- Boiling point:
- 262.3±20.0 °C(Predicted)
- Density
- 1.231±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- -0.83±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C9H9NO4/c1-13-8(11)6-4-3-5-10-7(6)9(12)14-2/h3-5H,1-2H3
- InChIKey
- YLGIBCYHQZTFQL-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CC=C1C(OC)=O
- CAS DataBase Reference
- 605-38-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,3-Pyridinedicarboxylic acid, dimethyl ester(605-38-9)
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Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S288039
- Product name
- PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- S288039
- Product name
- PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $179
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1303
- Product name
- Dimethyl 2,3-Pyridinedicarboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
TCI Chemical
- Product number
- P1303
- Product name
- Dimethyl 2,3-Pyridinedicarboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $136
- Updated
- 2025/07/31
TRC
- Product number
- D477770
- Product name
- Dimethyl 2,3-Pyridinedicarboxylate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
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2,3-Pyridinedicarboxylic acid dimethyl ester Chemical Properties,Usage,Production
Uses
Dimethyl 2,3-Pyridinedicarboxylate is a reagent in the preparation of diarylcyclopentenopyridines as endothelin receptor antagonists.
Synthesis
67-56-1
89-00-9
605-38-9
2,3-Pyridinedicarboxylic acid (80 g, 0.48 mol) was dissolved in methanol (400 ml) and stirred at room temperature for 30 minutes. Concentrated sulfuric acid (94.1 g, 0.96 mol) was then added slowly dropwise for about 1 hour. The reaction mixture was heated to 60°C and the reaction was stirred overnight. After completion of the reaction, methanol was removed by distillation under reduced pressure. The concentrate was slowly poured into aqueous sodium carbonate solution during which a large amount of gas was produced. The pH was adjusted to 7-8 and extracted with dichloromethane (1000 ml × 2). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give dimethyl 2,3-pyridinedicarboxylate as a pale yellow solid (89.7 g, 99% purity, 95.8% yield).
References
[1] Patent: CN105566319, 2016, A. Location in patent: Paragraph 0185; 0186; 0187; 0188
[2] Australian Journal of Chemistry, 1984, vol. 37, # 1, p. 87 - 94
[3] Patent: EP3252059, 2017, A1. Location in patent: Paragraph 0686; 0686-0688
[4] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 397 - 404
[5] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 433 - 450
2,3-Pyridinedicarboxylic acid dimethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Pyridinedicarboxylic acid dimethyl ester manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
- Price
- US $1000.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 200tons
- Release date
- 2025-08-13
Honest Joy Holdings Limited
- Product
- Dimethyl pyridine-2,3-dicarboxylate 605-38-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
Career Henan Chemical Co
- Product
- 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-25
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