saikogenin A

Product Name: saikogenin A
CAS No.: 5092-09-1
Chemical Name: saikogenin A
Synonyms: Clinopodiside A1;Saikogenin A, 10 mM in DMSO;Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-;Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase;(3S,4R,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
CBNumber: CB21340129
Molecular Formula: C30H48O4
Formula Weight: 472.7
MOL File: 5092-09-1.mol

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saikogenin A Property

Melting point:: 287-293 °C
Boiling point:: 607.4±55.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 14.47±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0034285
Product name: SaikogeninA
Purity: 98.31%
Packaging: 5mg
Price: $750
Updated: 2021/12/16

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saikogenin A Chemical Properties,Usage,Production

Biological Activity

Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor.

Biochem/physiol Actions

Saikogenin A is a naturally occurring plant extract that has been shown to have a variety of biological activities. saikogenin A has anti-inflammatory and tumour cell growth inhibiting effects. Its anti-inflammatory effect is due to an increase in corticosterone caused by the release of ACTH and has a direct effect on the inflammatory process. It also inhibits the absorption of ultraviolet light by human skin cells and erythromycin-induced UvB damage.

in vitro

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.

in vivo

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.

target

DPP-IV

saikogenin A Preparation Products And Raw materials

Raw materials

Preparation Products

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saikogenin A Suppliers

China 38 United States 2 Global 40

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5092-09-1, saikogenin ARelated Search:

laxogenin Saikosaponin F SAIKOGENIN D saikosaponin e Saikosaponin C Saikosaponin D Saikosaponin a 11(α)-methoxysaikosaponin F Saikosaponin B2 Saikosaponin B1 [16β,28-Dihydroxy-11,12,13,18-tetradehydrooleanan-3β-yl]4-O-(6-deoxy-α-L-mannopyranosyl)-6-O-(β-D-glucopyranosyl)-β-D-glucopyranoside

Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-

Clinopodiside A1

Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase

Saikogenin A, 10 mM in DMSO

(3S,4R,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol

5092-09-1