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gracillin

Product Name
gracillin
CAS No.
19083-00-2
Chemical Name
gracillin
Synonyms
Gracilline;DulcaMarinC;Gracillin-RM;LilioglycosideG;Gracillin 19083-00-2;Gracillin, 10 mM in DMSO;inhibit,Inhibitor,Gracillin;Diosgenin 3-O-β-gracillimatrioside;Diosgenin 3-O-beta-gracillimatrioside;Gracillin, 98%, from Dioscorea opposita Thunb.
CBNumber
CB21352494
Molecular Formula
C45H72O17
Formula Weight
885.04
MOL File
19083-00-2.mol
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gracillin Property

Melting point:
290-293℃ (DEC.)
Density 
1.42
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO, methanol and pyridine
form 
powder
pka
12.78±0.70(Predicted)
color 
White
InChI
InChI=1S/C15H20O3/c1-8-4-5-11(16)15(3)7-6-10-9(2)14(17)18-13(10)12(8)15/h9-10,13H,4-7H2,1-3H3
InChIKey
RSDQBPGKMDFRHH-UHFFFAOYSA-N
SMILES
C12=C(C)CCC(=O)C1(C)CCC1C(C(=O)OC21)C
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Safety

HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
G0637
Product name
Gracillin
Packaging
100MG
Price
$327
Updated
2025/07/31
Cayman Chemical
Product number
11848
Product name
Gracillin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11848
Product name
Gracillin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
11848
Product name
Gracillin
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
11848
Product name
Gracillin
Purity
≥95%
Packaging
25mg
Price
$420
Updated
2024/03/01
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gracillin Chemical Properties,Usage,Production

Description

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM). Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L. It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid in mice.

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the rhizomes of Dioscorea zingiberensis and Dioscorea parviflora.

Uses

Gracillin is a steroidal glycoside from the rhizomes of the family Dioscoreaceae with potential anti-proliferative effects.

Definition

ChEBI: Gracillin is a triterpenoid.

in vivo

Gracillin (oral gavage, 10?mg/kg for xenografts and 20?mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors[1].

References

[1] KE HU  Xinsheng Y. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro.[J]. Phytotherapy Research, 2003, 17 6: 620-626. DOI: 10.1002/ptr.1211
[2] WEI ZHENG. Antiparasitic efficacy of Gracillin and Zingibernsis newsaponin from Costus speciosus (Koen ex. Retz) Sm. against Ichthyophthirius multifiliis.[J]. Parasitology, 2015, 142 3: 473-479. DOI: 10.1017/s0031182014001358
[3] SUNG YONG KIM. Inhibition of mouse ear edema by steroidal and triterpenoid saponins[J]. Archives of Pharmacal Research, 1999, 22 3: 313-316. DOI: 10.1007/bf02976370

gracillin Preparation Products And Raw materials

Raw materials

Preparation Products

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gracillin Suppliers

China 186 India 1 United Kingdom 1 United States 16 Global 204
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Tel
025-84430028 13815430202
Email
sale02@cqherb.com
Country
China
ProdList
294
Advantage
59
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
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View Lastest Price from gracillin manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Gracillin 19083-00-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-22
Shanghai Standard Technology Co., Ltd.
Product
Gracillin 19083-00-2
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-27
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Gracillin 19083-00-2
Price
US $357.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
50kg
Release date
2020-03-04

19083-00-2, gracillinRelated Search:

Sclareol 3''-PRENYLDAIDZEIN DARUTIGENOL Valtrate Geraniol (R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one ORIENTIN Iodixanol Dioscin Protodioscin CETONAL Diosgenin PRENYL ISOBUTYRATE gracillin ETHYL 7-OXOUNDECANOATE TAURIN ETHYL 7-OXODECANOATE ETHYL 7-OXONONANOATE

  • Gracillin, 98%, from Dioscorea opposita Thunb.
  • (25R)-3β-(2-O-α-L-Rhamnopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyloxy)spirosta-5-ene
  • [(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-glucopyranosyl)-β-D-glucopyranoside
  • [(25R)-Spirosta-5-ene-3β-yl]3-O-β-D-glucopyranosyl-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside
  • Diosgenin 3-O-β-gracillimatrioside
  • Gracilline
  • Diosgenin 3-O-beta-gracillimatrioside
  • DulcaMarinC
  • LilioglycosideG
  • Gracillin 19083-00-2
  • β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-(((2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • inhibit,Inhibitor,Gracillin
  • Gracillin-RM
  • Gracillin, 10 mM in DMSO
  • 19083-00-2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract