sesaminol

Product Name: sesaminol
CAS No.: 74061-79-3
Chemical Name: sesaminol
Synonyms: sesaminol;1,3-Benzodioxol-5-ol, 6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-;(1S,3aβ,6aβ)-1β-(6-Hydroxy-1,3-benzodioxol-5-yl)-4β-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan;6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxol-5-ol
CBNumber: CB21352580
Molecular Formula: C20H18O7
Formula Weight: 370.35
MOL File: 74061-79-3.mol

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sesaminol Property

Boiling point:: 504.7±50.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
pka: 9.69±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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sesaminol Chemical Properties,Usage,Production

Uses

Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease[1].

Definition

ChEBI: Sesaminol is a furofuran that is cis-tetrahydro-1H,3H-furo[3,4-c]furan substituted by a 6-hydroxy-1,3-benzodioxol-5-yl group at position 1S and a 1,3-benzodioxol-5-yl group at position 4S. It is metabolite found in sesame seeds. It has a role as a plant metabolite and an antioxidant. It is a member of benzodioxoles, a furofuran and an organic hydroxy compound.

References

[1] Kaji H, et al., Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. Heliyon. 2020 Nov 2;6(11):e05342. DOI:10.1016/j.heliyon.2020.e05342

sesaminol Preparation Products And Raw materials

Raw materials

Preparation Products

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sesaminol Suppliers

China 8 USA 1 Global 9

Shanghai YuanYe Biotechnology Co., Ltd.

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Hubei Qifei Pharmaceutical Chemical Co., Ltd

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SHANGHAI ZZBIO CO., LTD.

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Chengdu Peter-like Biotechnology Co., Ltd.

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Funakoshi Co Ltd

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74061-79-3, sesaminolRelated Search:

Sesamin CROCEIN ORANGE G Sesamol RICINOLEYL ALCOHOL Sesame flavor

(1S,3aβ,6aβ)-1β-(6-Hydroxy-1,3-benzodioxol-5-yl)-4β-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan

sesaminol

6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxol-5-ol

1,3-Benzodioxol-5-ol, 6-[(1S,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-

74061-79-3