N 556

Product Name: N 556
CAS No.: 110816-78-9
Chemical Name: N 556
Synonyms: N 556;KY-556;KY556,KY 556;5,5'-[[2-(Lysyloxy)propane-1,3-diyl]bisoxy]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl]·2hydrochloride
CBNumber: CB21363858
Molecular Formula: C33H36N2O12.2ClH
Formula Weight: 725.571
MOL File: 110816-78-9.mol

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N 556 Property

Melting point:: 225-228 °C
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N 556 Chemical Properties,Usage,Production

Uses

KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.

in vivo

The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats^[1].

References

[1] Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PMID:2096808

N 556 Preparation Products And Raw materials

Raw materials

Preparation Products

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N 556 Suppliers

China 6 United States 4 Global 10

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110816-78-9, N 556Related Search:

2,2’-(1,3-Propanediyldioxy)bisbenzaldehyde 5-HYDROXY-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID 1-[2-(2-ETHOXYETHOXY)-6-HYDROXYPHENYL]ETHAN-1-ONE ETHYL 5-METHOXY-4-OXO-1,4-DIHYDRONAPHTHALENE-2-CARBOXYLATE methyl DL-lysinate dihydrochloride o-Tolyl-alpha-myanesin Methyl L-lysinate dihydrochloride Diethyl cromoglycate ETHYL 2,6-DIAMINOHEXANOATE DIHYDROCHLORIDE Ethyl 2,6-diaminohexanoate dihydrochloride N 556 ethyl 4-oxo-4H-1-benzopyran-2-carboxylate ethyl L-lysinate monohydrochloride Cromoglicic acid

N 556

5,5'-[[2-(Lysyloxy)propane-1,3-diyl]bisoxy]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl]·2hydrochloride

KY-556

KY556,KY 556

110816-78-9