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hamaudol

Product Name
hamaudol
CAS No.
735-46-6
Chemical Name
hamaudol
Synonyms
hamaudol;Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit;(S)-3,5-Dihydroxy-2,2,8-trimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one;(S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one;2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-
CBNumber
CB21363984
Molecular Formula
C15H16O5
Formula Weight
276.28
MOL File
735-46-6.mol
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hamaudol Property

Melting point:
197.0-197.5 °C
Boiling point:
464.7±45.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
6.77±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0100499
Product name
Hamaudol
Packaging
5mg
Price
$336
Updated
2021/12/16
ChemScene
Product number
CS-0100499
Product name
Hamaudol
Packaging
10mg
Price
$571
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594459
Product name
Hamaudol
Packaging
20mg
Price
$591.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594459
Product name
Hamaudol
Packaging
100mg
Price
$1757.8
Updated
2021/12/16
AK Scientific
Product number
1210CB
Product name
Hamaudol
Packaging
500mg
Price
$4775
Updated
2021/12/16
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hamaudol Chemical Properties,Usage,Production

Uses

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

Definition

ChEBI: Hamaudol is a member of chromenes.

Biological Activity

Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects.

in vivo

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.

< b>

target

COX-1

< span> 0.3 mM (IC 50 )

COX-2

0.57 mM (IC 50 )

IC 50

COX-1: 0.3 mM (IC50); COX-2: 0.57 mM (IC50)

References

[1] Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. DOI:10.1248/cpb.49.154
[2] Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).

hamaudol Preparation Products And Raw materials

Raw materials

Preparation Products

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hamaudol Suppliers

China 41 United States 3 Global 44
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

735-46-6, hamaudolRelated Search:

GARDENIN B PONCIRIN Quercetin-7-O-β-D-glucopyranoside MEDICAGOL MOSLOFLAVONE hydroxygenkwanin CIMIFUGIN BETA-D-GLUCOPYRANOSIDE 4-O-BETA-D-GULCOSYL-5-O-METHYLVISAMMINOL 4',5-DIHYDROXY-7-METHOXYFLAVONE 3-O-Acetylhamaudol 5-O-Methylvisammioside, 6''-O-apiosyl- SEC-O-GLUCOSYLHAMAUDOL 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Naringenin Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)

  • hamaudol
  • (S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
  • 2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-
  • Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit
  • (S)-3,5-Dihydroxy-2,2,8-trimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one
  • 735-46-6