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Selegiline

Product Name
Selegiline
CAS No.
14611-51-9
Chemical Name
Selegiline
Synonyms
SELEGILINE;Emsam;SELEGILINE BASE;BenzeneethanaMine, N,a-diMethyl-N-2-propyn-1-yl-, (aR)-;C07245;Selgene;Zelapar;Selegina;SELEGELIN;Emsam TTS
CBNumber
CB2137450
Molecular Formula
C13H17N
Formula Weight
187.28
MOL File
14611-51-9.mol
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Selegiline Property

Melting point:
137.5-139 °C
alpha 
D20 -11.2°
Boiling point:
273℃
Density 
0.954
refractive index 
nD20 1.5180
Flash point:
108℃
storage temp. 
-20°C
pka
7.53±0.50(Predicted)
InChI
InChI=1/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/s3
InChIKey
MEZLKOACVSPNER-PLAQIDKDNA-N
SMILES
C1(C=CC=CC=1)C[C@@H](C)N(C)CC#C |&1:7,r|
CAS DataBase Reference
14611-51-9
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
1851
WGK Germany 
1
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S-003
Product name
R(-)-Selegiline solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$86.7
Updated
2022/05/15
Medical Isotopes, Inc.
Product number
16877
Product name
R(-)-Selegiline[(-)-Deprenyl]
Packaging
1mg
Price
$535
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009080
Product name
SELEGILINE
Purity
95.00%
Packaging
1G
Price
$770.1
Updated
2021/12/16
AvaChem
Product number
3964B
Product name
Selegiline
Packaging
100mg
Price
$119
Updated
2021/12/16
AvaChem
Product number
3964B
Product name
Selegiline
Packaging
25mg
Price
$49
Updated
2021/12/16
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Selegiline Chemical Properties,Usage,Production

Description

Selegiline, a monoamine oxidase (MAO) inhibitor, is FDA-approved as an adjunct treatment in the management of patients with Parkinson disease and as a treatment for a major depressive disorder (MDD) in adults. Selegiline is also used off-label for early Parkinson disease and the treatment of attention-deficit/hyperactivity disorder (ADHD). 

Uses

Antidyskinetic; antiparkinsonian (in combination with levodopa/carbidopa).

Uses

This drug is a selective inhibitor of monoaminooxidase B, which suppresses dopamineinactivation processes and facilitates an increase of its level in the brain. In treating Parkinsonism, selegiline is usually used in combination with levodopa.

Definition

ChEBI:(-)-selegiline is a selegiline and a terminal acetylenic compound. It has a role as a geroprotector. It is a conjugate base of a (-)-selegiline(1+).

brand name

Emsam (Somerset).

World Health Organization (WHO)

Selegiline was introduced in the early 1990s. It is a monoamine oxidase inhibitor and is used in the management of Parkinson's disease. A symptomatic effect of selegiline in Parkinson's disease has been shown, but longer follow-up failed to provide any definitive evidence of ability to retard the loss of dopaminergic neurons (Parkinson's Study Group, 1993).

Biological Functions

Another drug used in the treatment of Parkinson’s disease is selegiline (also known as deprenyl, or Eldepryl). It is an irreversible inhibitor of MAO-B, an important enzyme in the metabolism of dopamine (Fig. 33.2). Blockade of dopamine metabolism makes more dopamine available for stimulation of its receptors. Selegiline, as monotherapy, may be effective in the newly diagnosed patient with parkinsonism because its pharmacological effect enhances the actions of endogenous dopamine.
Selegiline is also used in conjunction with levodopa– carbidopa in later-stage parkinsonism to reduce levodopa dosage requirements and to minimize or delay the onset of dyskinesias and motor fluctuations that usually accompany long-term treatment with levodopa. It has also been proposed that selegiline may slow the progression of the disease by reducing the formation of toxic free radicals produced during the metabolism of dopamine. However, any neuroprotective effect of selegiline in parkinsonian patients remains to be established.
Most of the adverse reactions to selegiline are related to actions of increased levels of dopamine, as discussed earlier. At recommended doses, and unlike the nonselective MAO inhibitors used in the treatment of depression, selegiline has little effect on MAO-A and therefore generally does not cause the hypertension associated with the ingestion of tyramine-enriched foods. However, at doses higher than those usually recommended, MAO-A may be inhibited, which increases the risk of a tyramine reaction.
Selegiline should not be coadministered with tricyclic antidepressants or selective serotonin uptake inhibitors because of the possibility of a severe adverse drug reaction (e.g., hyperpyrexia, agitation, delirium, coma).

Synthesis

Selegiline, N-methyl-N-(2-propinyl)-2-methyl-1-phenylethylamine (10.1.14), is synthesized by the alkylation of (-)methyamphetamine (8.1.2.3) using propargylbromide [20¨C23].

Selegiline Preparation Products And Raw materials

Raw materials

Preparation Products

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Selegiline Suppliers

MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
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View Lastest Price from Selegiline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Selegiline 14611-51-9
Price
US $0.00/g
Min. Order
10g
Purity
95%~98%
Supply Ability
20kg/month
Release date
2021-07-28
Career Henan Chemical Co
Product
SELEGILINE 14611-51-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%HPLC
Supply Ability
200KG
Release date
2020-02-01

14611-51-9, SelegilineRelated Search:


  • SELEGILINE BASE
  • dl-Depreny
  • phenylisopropyl-n-MethylpropinylaMine
  • BenzeneethanaMine, N,a-diMethyl-N-2-propyn-1-yl-, (aR)-
  • R(-)-Selegiline solution
  • SELEGELIN
  • SELEGILINE
  • R(-)-SELEGILINE
  • N-(Methyl-d3),a-methyl-N-2-propyn-1-yl-benzeneethanamine
  • N-(Methyl-d3),a-methyl-N-2-propynyl Phenethylamine
  • SELEGILINEHYDROCHLORDE
  • (R)-(-)-Deprenyl
  • Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (aR)- (9CI)
  • Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (R)-
  • l-Deprenyl
  • Phenethylamine, N,a-dimethyl-N-2-propynyl-, L-(-)- (8CI)
  • (αR)-N,α-Dimethyl-N-(2-propynyl)benzeneethanamine
  • N-Methyl-N-[(R)-1-benzylethyl]-2-propyne-1-amine
  • C07245
  • (R)-N,alpha-Dimethyl-N-2-propynylbenzeneethanamine
  • Emsam
  • Emsam TTS
  • Selegina
  • Selgene
  • Zelapar
  • (-)-DEPRENYL
  • (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
  • Selegiline hydrochloride CRS
  • (RS)-Selegiline hydrochloride CRS
  • Benzeneethanamine, N,α-dimethyl-N-2-propyn-1-yl-, (αR)-
  • SELEGILINE USP/EP/BP
  • (-)-selegiline
  • (-)-Deprenyl
  • Ethanol,2,2'-[1,5-naphthalenediylbis(oxy-2,5-ethanediyloxy)]bis-
  • SELEGILINE
  • SELEGILINE
  • 14611-51-9