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illudin M

Product Name: illudin M
CAS No.: 1146-04-9
Chemical Name: illudin M
Synonyms: illudin M;(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one;(3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one;Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-
CBNumber: CB21385676
Molecular Formula: C15H20O3
Formula Weight: 248.32
MOL File: 1146-04-9.mol

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illudin M Property

Melting point:: 120-122.5° (Matsumoto); mp 128-130° (McMorris)
Boiling point:: 452.4±45.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form: A solid
pka: 12.57±0.70(Predicted)
color: Off-white to light yellow
InChI: InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1
InChIKey: QVMDIQLUNODCTG-OCCSQVGLSA-N
SMILES: C12([C@](O)(C)C(=O)C3C(=C1C)[C@@H](O)C(C)(C)C=3)CC2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22062
Product name: Illudin M
Purity: ≥95%
Packaging: 1mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 22062
Product name: Illudin M
Purity: ≥95%
Packaging: 5mg
Price: $1169
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0025316
Product name: ILLUDIN M
Purity: 95.00%
Packaging: 5MG
Price: $496.64
Updated: 2021/12/16

ChemScene

Product number: CS-0085822
Product name: IlludinM
Packaging: 1mg
Price: $540
Updated: 2021/12/16

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illudin M Chemical Properties,Usage,Production

Description

Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It is cytotoxic to HL-60 human leukemia cells at 6-100 nM. Illudin M was used as a base structure for the development of potential anticancer agents with less toxicity and improved efficacy. It is closely related to illudin S , which has been the focus of additional studies.

Uses

Illudin M is a cytotoxic sesquiterpene from Omphalotus illudens and Granulobasidium vellereum. It acts as an alkylating agent that can cause inhibition of cell growth or replication.

Definition

ChEBI: Illudin M is a sesquiterpenoid.

References

[1] J. JACOBSON. Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John’s Wort Plant, in Patients with Chronic Hepatitis C Virus Infection[J]. Antimicrobial Agents and Chemotherapy, 2001, 45 1: 517-524. DOI: 10.1128/aac.45.2.517-524.2001
[2] M J KELNER. Preclinical evaluation of illudins as anticancer agents.[J]. Cancer research, 1987, 47 12: 3186-3189.
[3] R SCHOBERT. Anticancer active illudins: recent developments of a potent alkylating compound class.[J]. Current medicinal chemistry, 2011, 18 6: 790-807. DOI: 10.2174/092986711794927766

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View Lastest Price from illudin M manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: illudin M 1146-04-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10 tons
Release date: 2024-08-16

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illudin M

(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one

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1146-04-9

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