illudin S
- Product Name
- illudin S
- CAS No.
- 1149-99-1
- Chemical Name
- illudin S
- Synonyms
- CS-1385;Illudin;Lunamycin;Lampterol;Illusin S;illudin S;NSC 400979;NSC-626369;Illudine S;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
- CBNumber
- CB91318110
- Molecular Formula
- C15H20O4
- Formula Weight
- 264.32
- MOL File
- 1149-99-1.mol
illudin S Property
- Melting point:
- 124-126℃
- Boiling point:
- 327.55°C (rough estimate)
- Density
- 1.0583 (rough estimate)
- refractive index
- 1.4300 (estimate)
- storage temp.
- -20°C, Inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- A light yellow solid
- pka
- 12.50±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 17451
- Product name
- Illudin S
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 17451
- Product name
- Illudin S
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $1208
- Updated
- 2024/03/01
- Product number
- C4732
- Product name
- IlludinS
- Packaging
- 5mg
- Price
- $1381
- Updated
- 2021/12/16
- Product number
- C4732
- Product name
- IlludinS
- Packaging
- 1mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- INB0003821
- Product name
- ILLUDIN S
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.42
- Updated
- 2021/12/16
illudin S Chemical Properties,Usage,Production
Description
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.
Uses
Illudin S is a potent antitumor sesquiterpene.
Uses
Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
Definition
ChEBI: Illudin S is a sesquiterpenoid.
illudin S Preparation Products And Raw materials
Raw materials
Preparation Products
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