illudin S

Product Name: illudin S
CAS No.: 1149-99-1
Chemical Name: illudin S
Synonyms: CS-1385;Illudin;Lunamycin;Lampterol;Illusin S;illudin S;llludin S;NSC 400979;NSC-626369;Illudine S
CBNumber: CB91318110
Molecular Formula: C15H20O4
Formula Weight: 264.32
MOL File: 1149-99-1.mol

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illudin S Property

Melting point:: 124-126℃
Boiling point:: 327.55°C (rough estimate)
Density: 1.0583 (rough estimate)
refractive index: 1.4300 (estimate)
storage temp.: -20°C, Inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: A light yellow solid
pka: 12.50±0.70(Predicted)
color: Off-white to yellow
InChI: InChI=1S/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1
InChIKey: DDLLIYKVDWPHJI-RDBSUJKOSA-N
SMILES: C12([C@](O)(C)C(=O)C3C(=C1C)[C@@H](O)[C@@](CO)(C)C=3)CC2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17451
Product name: Illudin S
Purity: ≥98%
Packaging: 1mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 17451
Product name: Illudin S
Purity: ≥98%
Packaging: 5mg
Price: $1208
Updated: 2024/03/01

ApexBio Technology

Product number: C4732
Product name: IlludinS
Packaging: 1mg
Price: $345
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0003821
Product name: ILLUDIN S
Purity: 95.00%
Packaging: 5MG
Price: $495.42
Updated: 2021/12/16

ChemScene

Product number: CS-0089316
Product name: IlludinS
Packaging: 1mg
Price: $530
Updated: 2021/12/16

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illudin S Chemical Properties,Usage,Production

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G₁-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC₅₀ = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

Uses

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

Uses

Illudin S is a potent antitumor sesquiterpene.

Definition

ChEBI: Illudin S is a sesquiterpenoid.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NICOLAAS G.J JASPERS . Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways[J]. DNA Repair, 2002, 1 12: Pages 1027-1038. DOI: 10.1016/s1568-7864(02)00166-0

illudin S Preparation Products And Raw materials

Raw materials

Preparation Products

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illudin S Suppliers

China 77 India 1 United Kingdom 1 United States 9 Global 88

Zhejiang Huida Biotech Co., LTD

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Chembest Research Laboratories Limited

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T&W GROUP

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Hubei widely chemical technology Co., Ltd.

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Wuhan Wsem Biological Co., Ltd.

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Email: 13667159345@163.com
Country: China
ProdList: 1997
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View Lastest Price from illudin S manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: illudin S 1149-99-1
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-10-31

Shaanxi Dideu Medichem Co. Ltd

Product: illudin S 1149-99-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10 tons
Release date: 2024-08-17

1149-99-1, illudin SRelated Search:

PROTOPANAXDIOL Lupeol Quillaic acid Cryptochlorogenic acid Cryptotanshinone DEMETON S illudin M (S)-1-CYCLOPROPYLETHANOL FEMA 3766 1-CYCLOPROPYL-PROPAN-2-ONE 3-METHYL-3-CYCLOHEXEN-1-ONE 2,2,4,6,6-PENTAMETHYL-3-HEPTENE illudin S 1-CYCLOPROPYL-1-METHYLETHANOL 3,5,5-trimethylcyclohex-3-en-1-one 1-(1-METHYLCYCLOPROPYL)ACETONE ISO-PROPENYLCYCLOPROPANE

illudin S

(2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one

Illusin S

Lampterol

NSC-626369

(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one

Illudin

Illudine S

Lunamycin

NSC 400979

CS-1385

Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)-

(2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one

llludin S

1149-99-1

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