Cryptotanshinone
- Product Name
- Cryptotanshinone
- CAS No.
- 35825-57-1
- Chemical Name
- Cryptotanshinone
- Synonyms
- CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
- CBNumber
- CB4222031
- Molecular Formula
- C19H20O3
- Formula Weight
- 296.36
- MOL File
- 35825-57-1.mol
Cryptotanshinone Property
- Melting point:
- 192°C(lit.)
- Boiling point:
- 459.0±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- form
- powder
- color
- orange-brown
- optical activity
- [α]/D -85.0±3.0°, c = 0.1 in chloroform
- λmax
- 263nm(lit.)
- BRN
- 5445400
- InChIKey
- IJSBKZLSTIFYIE-FPKDZHNTSA-N
- LogP
- 4.130 (est)
- CAS DataBase Reference
- 35825-57-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHL89612
- Product name
- Cryptotanshinone
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $584
- Updated
- 2024/03/01
- Product number
- C3363
- Product name
- Cryptotanshinone
- Purity
- >97.0%(HPLC)
- Packaging
- 25mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- C3363
- Product name
- Cryptotanshinone
- Purity
- >97.0%(HPLC)
- Packaging
- 100mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 16987
- Product name
- Cryptotanshinone
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16987
- Product name
- Cryptotanshinone
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
Cryptotanshinone Chemical Properties,Usage,Production
Chemical Properties
Orange powder
Uses
inhibits angiogenesis
Uses
Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.
Definition
ChEBI: Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent.
General Description
Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
Biological Activity
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.
Biochem/physiol Actions
Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.
Cytotoxicity
IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)
storage
Room temperature
Cryptotanshinone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cryptotanshinone manufacturers
- Product
- Cryptotanshinone 35825-57-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-25
- Product
- Cryptotanshinone 35825-57-1 35825-57-1
- Price
- US $5.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-17
- Product
- Cryptotanshinone 35825-57-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10