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Cryptotanshinone

Product Name
Cryptotanshinone
CAS No.
35825-57-1
Chemical Name
Cryptotanshinone
Synonyms
CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
CBNumber
CB4222031
Molecular Formula
C19H20O3
Formula Weight
296.36
MOL File
35825-57-1.mol
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Cryptotanshinone Property

Melting point:
192°C(lit.)
Boiling point:
459.0±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
form 
powder
color 
orange-brown
optical activity
[α]/D -85.0±3.0°, c = 0.1 in chloroform
λmax
263nm(lit.)
BRN 
5445400
InChIKey
IJSBKZLSTIFYIE-FPKDZHNTSA-N
LogP
4.130 (est)
CAS DataBase Reference
35825-57-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T,N
Risk Statements 
25-50/53
Safety Statements 
45-60-61
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
SF8282645
HazardClass 
6.1
PackingGroup 
III
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89612
Product name
Cryptotanshinone
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$584
Updated
2024/03/01
TCI Chemical
Product number
C3363
Product name
Cryptotanshinone
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$152
Updated
2024/03/01
TCI Chemical
Product number
C3363
Product name
Cryptotanshinone
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
16987
Product name
Cryptotanshinone
Purity
≥95%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16987
Product name
Cryptotanshinone
Purity
≥95%
Packaging
10mg
Price
$57
Updated
2024/03/01
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Cryptotanshinone Chemical Properties,Usage,Production

Chemical Properties

Orange powder

Uses

inhibits angiogenesis

Uses

Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.

Definition

ChEBI: Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent.

General Description

Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.

Biochem/physiol Actions

Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.

Cytotoxicity

IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)

storage

Room temperature

Cryptotanshinone Preparation Products And Raw materials

Raw materials

Preparation Products

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Cryptotanshinone Suppliers

cfm Oskar Tropitzsch
Tel
--
Fax
--
Country
Germany
ProdList
1136
Advantage
62
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Cryptotanshinone manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Cryptotanshinone 35825-57-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-25
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Cryptotanshinone 35825-57-1 35825-57-1
Price
US $5.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cryptotanshinone 35825-57-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

35825-57-1, CryptotanshinoneRelated Search:


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