dimebolin
- Product Name
- dimebolin
- CAS No.
- 3613-73-8
- Chemical Name
- dimebolin
- Synonyms
- CS-151;dimebon;Dimebone;dimebolin;Dimeboline;Brn 0622478;Latrepirdine;Preparation-84;DiMebon (latrepirdine);Dimebolin Exclusive
- CBNumber
- CB21386820
- Molecular Formula
- C21H25N3
- Formula Weight
- 319.44
- MOL File
- 3613-73-8.mol
dimebolin Property
- Melting point:
- 115-116 °C
- Boiling point:
- 448.46°C (rough estimate)
- Density
- 1.13
- refractive index
- 1.6380 (estimate)
- storage temp.
- Store at -20°C
- solubility
- ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 9.05±0.20(Predicted)
- CAS DataBase Reference
- 3613-73-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9000556
- Product name
- Dimebolin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $21
- Updated
- 2024/03/01
- Product number
- 9000556
- Product name
- Dimebolin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 9000556
- Product name
- Dimebolin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $157
- Updated
- 2024/03/01
- Product number
- 9000556
- Product name
- Dimebolin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 255148
- Product name
- Dimebon dihydrochloride
- Packaging
- 1mg
- Price
- $360
- Updated
- 2021/12/16
dimebolin Chemical Properties,Usage,Production
Uses
Non-steroidal anti-inflammatory with analgesic and antipyretic effects
Definition
ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.
Biological Activity
dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].
References
[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.
dimebolin Preparation Products And Raw materials
Raw materials
Preparation Products
dimebolin Suppliers
- Tel
- 021-20221225 13917446399
- Fax
- QQ:115820162
- sales@zhiwe.net
- Country
- China
- ProdList
- 604
- Advantage
- 61
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9414
- Advantage
- 66
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8844
- Advantage
- 52
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1922
- Advantage
- 55
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
View Lastest Price from dimebolin manufacturers
- Product
- dimebolin 3613-73-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-11
- Product
- Latrepirdine 3613-73-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10