dimebolin

ChemicalBook > CAS DataBase List > dimebolin

Product Name: dimebolin
CAS No.: 3613-73-8
Chemical Name: dimebolin
Synonyms: CS-151;dimebon;Dimebone;dimebolin;Dimeboline;Brn 0622478;Latrepirdine;Preparation-84;DiMebon (latrepirdine);Dimebolin Exclusive
CBNumber: CB21386820
Molecular Formula: C21H25N3
Formula Weight: 319.44
MOL File: 3613-73-8.mol

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dimebolin Property

Melting point:: 115-116 °C
Boiling point:: 448.46°C (rough estimate)
Density: 1.13
refractive index: 1.6380 (estimate)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide
form: crystalline solid
pka: 9.05±0.20(Predicted)
CAS DataBase Reference: 3613-73-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9000556
Product name: Dimebolin
Purity: ≥98%
Packaging: 1mg
Price: $21
Updated: 2024/03/01

Cayman Chemical

Product number: 9000556
Product name: Dimebolin
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 9000556
Product name: Dimebolin
Purity: ≥98%
Packaging: 10mg
Price: $157
Updated: 2024/03/01

Cayman Chemical

Product number: 9000556
Product name: Dimebolin
Purity: ≥98%
Packaging: 25mg
Price: $341
Updated: 2024/03/01

Usbiological

Product number: 255148
Product name: Dimebon dihydrochloride
Packaging: 1mg
Price: $360
Updated: 2021/12/16

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dimebolin Chemical Properties,Usage,Production

Uses

Non-steroidal anti-inflammatory with analgesic and antipyretic effects

Definition

ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.

Biological Activity

dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].

References

[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.

dimebolin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from dimebolin manufacturers

Dideu Industries Group Limited

Product: dimebolin 3613-73-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-11

Career Henan Chemical Co

Product: Latrepirdine 3613-73-8
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

3613-73-8, dimebolinRelated Search:

Tetrahydrofurfuryl alcohol Dapagliflozin Saxagliptin Boc-3-Hydroxy-1-adamantyl-D-glycine 5-METHYLGRAMINE 3-Pyridineethaneamine dimebolin 2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2,5-Dimethylindole 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole (1-Methyl-1H-indol-3-yl)-methylamine 1-METHYL-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDINE 2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE 2,3,4,5-TETRAHYDRO-8-METHYL-1H-PYRIDO[4,3-B]INDOLE 1H-PYRROLE-3-METHANAMINE, 1-METHYL- RARECHEM AN KA 0161 METHYL-(5-METHYL-1H-INDOL-3-YLMETHYL)-AMINE 2-(6-METHYLPYRIDIN-3-YL)ETHANAMINE

dimebolin

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole

Dimeboline

Dimebone

Preparation-84

dimebon

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole

1H-Pyrido(4,3-B)indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-

CS-151

2,3,4,5-Tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)-ethyl)-1H-pyrid(4,3B)indole

Brn 0622478

Dimebon dihydrochloride

Dimebolin-Dihydrochloride

2,8-Dimethyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Dimebolin

2,8-Dimethyl-5-[2-(6-methyl-pyridin-3-yl)-ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

DiMebon dihydrochloride hydrate

2,8-DiMethyl-5-[2-(6-Methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

DiMebon (latrepirdine)

Latrepirdine

2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole

Dimebolin Exclusive

1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-

dimebolin ISO 9001：2015 REACH

3613-73-8