QS 21
- Product Name
- QS 21
- CAS No.
- 141256-04-4
- Chemical Name
- QS 21
- Synonyms
- CL130;QA 21;QS 21;QA 21V1;QS-21-Api;QS-21 saponin;QS-21 ADJUVANT;Saponin QA 21V1;β-D-Glucopyranosiduronic acid, (3β,4α,16α)-28-[[O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-O-[5-[[5-(α-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-β-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoole...;(2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-(((3S,5S,6S)-5-(((3S,5S,6S)-5-(((2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-h
- CBNumber
- CB21396474
- Molecular Formula
- C92H148O46
- Formula Weight
- 1990.13
- MOL File
- 141256-04-4.mol
QS 21 Property
- Density
- 1.52±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Store at -20°C
- pka
- 2.68±0.70(Predicted)
- form
- Solid
- color
- White to light yellow
- InChIKey
- CNEYUDLWGDOPIY-VWDQBTOUNA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PXT0004773
- Product name
- QS 21
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.41
- Updated
- 2021/12/16
QS 21 Chemical Properties,Usage,Production
Uses
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].
in vivo
Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].
IC 50
NLRP3 inflammasome
References
[1] Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756. DOI:10.1021/acs.accounts.6b00242
[2] Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136 DOI:10.1074/jbc.M115.683011
[3] Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905. DOI:10.1016/j.phymed.2019.152905
QS 21 Preparation Products And Raw materials
Raw materials
Preparation Products
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