galiellalactone

Product Name: galiellalactone
CAS No.: 133613-71-5
Chemical Name: galiellalactone
Synonyms: galiellalactone;SOIISBQQYAGDKM-QJSROADHSA-N;(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one;Indeno[1,7-bc]furan-2(4H)-one, 5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-, (4S,5aR,7aR,7bS)-
CBNumber: CB21397587
Molecular Formula: C11H14O3
Formula Weight: 194.23
MOL File: 133613-71-5.mol

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galiellalactone Property

Boiling point:: 400.7±38.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:0.97(Max Conc. mg/mL);4.99(Max Conc. mM)
Ethanol:0.97(Max Conc. mg/mL);4.99(Max Conc. mM)
form: White to light tan solid.
pka: 12.48±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15387
Product name: Galiellalactone
Purity: ≥95%
Packaging: 1mg
Price: $371
Updated: 2024/03/01

Cayman Chemical

Product number: 15387
Product name: Galiellalactone
Packaging: 500μg
Price: $219
Updated: 2024/03/01

Cayman Chemical

Product number: 15387
Product name: Galiellalactone
Purity: ≥95%
Packaging: 5mg
Price: $1196
Updated: 2024/03/01

Tocris

Product number: 6218
Product name: Galiellalactone
Purity: ≥95%(HPLC)
Packaging: 500U
Price: $229
Updated: 2021/12/16

Usbiological

Product number: G1044-62
Product name: Galiellalactone
Packaging: 1mg
Price: $523
Updated: 2021/12/16

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galiellalactone Chemical Properties,Usage,Production

Description

Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC₅₀ value of 0.25-0.5 μM. The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.

Uses

Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.

Uses

Galiellalactone is a STAT3 inhibitor; active in vivo. Galiellalactone is also a promising compound for the development of future prostate cancer drugs.

storage

Store at -20°C

galiellalactone Preparation Products And Raw materials

Raw materials

Preparation Products

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galiellalactone Suppliers

China 22 United Kingdom 2 United States 8 Global 32

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133613-71-5, galiellalactoneRelated Search:

galiellalactone

SOIISBQQYAGDKM-QJSROADHSA-N

(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one

Indeno[1,7-bc]furan-2(4H)-one, 5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-, (4S,5aR,7aR,7bS)-

133613-71-5