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heptelidic acid

Product Name
heptelidic acid
CAS No.
57710-57-3
Chemical Name
heptelidic acid
Synonyms
Avocettin;Koningic acid;heptelidic acid;(5aS,9S)-1,5aβ,6,7,8,9aα-Hexahydro-6β-isopropyl-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid;(5aS,9S)-1,5a,6,7,8,9aα-Hexahydro-6β-(1-methylethyl)-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid;Spiro[2-benzoxepin-9(3H),2'-oxirane]-4-carboxylic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, (2'S,5aS,6R,9aS)-
CBNumber
CB21398115
Molecular Formula
C15H20O5
Formula Weight
280.32
MOL File
57710-57-3.mol
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heptelidic acid Property

Boiling point:
501.1±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form 
A solid
pka
3.68±0.40(Predicted)
color 
Colorless to off-white
LogP
2.034 (est)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14079
Product name
Heptelidic Acid
Purity
≥95%
Packaging
250μg
Price
$127
Updated
2024/03/01
Cayman Chemical
Product number
14079
Product name
Heptelidic Acid
Purity
≥95%
Packaging
1mg
Price
$397
Updated
2024/03/01
Usbiological
Product number
044883
Product name
Heptelidic acid
Packaging
250ug
Price
$350
Updated
2021/12/16
Usbiological
Product number
169990
Product name
Heptelidic Acid
Packaging
250ug
Price
$378
Updated
2021/12/16
TRC
Product number
H281015
Product name
HeptelidicAcid
Packaging
2.5mg
Price
$2145
Updated
2021/12/16
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heptelidic acid Chemical Properties,Usage,Production

Uses

Heptalidic acid is a?sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also?inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase.

in vivo

Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3].

Animal Model:6-week old female Foxn1nu mice bearing BT-474 tumor[3]
Dosage:1, 2.5, 5, and 10 mg/kg
Administration:Daily intraperitoneal (IP) injections, 24 hours
Result:1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).

IC 50

Caspase-3

heptelidic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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heptelidic acid Suppliers

China 44 India 1 United States 3 USA 1 Global 49
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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57710-57-3, heptelidic acidRelated Search:

ETHYL (S)-3,4-EPOXYBUTANOATE ETHYL 2-HYDROXYCYCLOHEXANECARBOXYLATE (2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID ALLYL 2-ETHYLBUTYRATE 3-(2-ethylbutoxy)propionic acid ETHYL (1S,2S)-TRANS-2-HYDROXYCYCLOHEXANECARBOXYLATE heptelidic acid

  • heptelidic acid
  • (5aS,9S)-1,5a,6,7,8,9aα-Hexahydro-6β-(1-methylethyl)-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid
  • (5aS,9S)-1,5aβ,6,7,8,9aα-Hexahydro-6β-isopropyl-1-oxospiro[2-benzoxepine-9(3H),2'-oxirane]-4-carboxylic acid
  • Avocettin
  • Koningic acid
  • Spiro[2-benzoxepin-9(3H),2'-oxirane]-4-carboxylic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, (2'S,5aS,6R,9aS)-
  • 57710-57-3