2-HYDROXYOLEICACID
- Product Name
- 2-HYDROXYOLEICACID
- CAS No.
- 56472-29-8
- Chemical Name
- 2-HYDROXYOLEICACID
- Synonyms
- 2OHOA;Minerval;Acumapimod;-d17 Minerva-d17l;2-HYDROXYOLEICACID;α-Hydroxyoleic Acid;(Rac)-Idroxioleic acid;α-Hydroxyoleic Acid-d17;cis-2-Hydroxy-9-octadecenoic Acid;(Z)-2-Hydroxyoctadec-9-enoic acid
- CBNumber
- CB21403596
- Molecular Formula
- C18H34O3
- Formula Weight
- 298.46
- MOL File
- 56472-29-8.mol
2-HYDROXYOLEICACID Property
- Melting point:
- 47-50oC
- storage temp.
- room temp
- solubility
- DMSO: >20mg/mL
- form
- Solid
- color
- white to tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0256
- Product name
- 2OHOA
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- SML0256
- Product name
- 2OHOA
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $523
- Updated
- 2024/03/01
- Product number
- H948765
- Product name
- 2-HydroxyOleicAcid
- Packaging
- 250mg
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- 014206
- Product name
- 2-Hydroxy Oleic Acid
- Packaging
- 25mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- API0017712
- Product name
- (9Z)-2-HYDROXY-9-OCTADECENOIC ACID
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $315
- Updated
- 2021/12/16
2-HYDROXYOLEICACID Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Beige Solid
Uses
2OHOA has been used as:
- a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
- in biophysical studies to study its effects on artificial membranes
- to study its interactions with major membrane lipid films
Uses
An oleic acid synthetic analog that is an effective non-toxic anticancer drug with a wide spectrum against different types of cancer. An antihypertensive.
Definition
ChEBI: 2-hydroxyoleic acid is a 2-hydroxy fatty acid that is oleic acid which carries a hydroxy group at position 2. It is an orally bioavailable synthetic hydroxylated fatty acid which modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. It has a role as an antineoplastic agent, an apoptosis inducer and an antihypertensive agent. It is a 2-hydroxy fatty acid, a long-chain fatty acid and a hydroxy monounsaturated fatty acid. It is functionally related to an oleic acid. It is a conjugate acid of a 2-hydroxyoleate.
Biochem/physiol Actions
2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in?membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.