Cyclobutyl bromide
- Product Name
- Cyclobutyl bromide
- CAS No.
- 4399-47-7
- Chemical Name
- Cyclobutyl bromide
- Synonyms
- BROMOCYCLOBUTANE;obutane;Cyclobutyl halide;CYCLOBUTYL BROMIDE;Cyclobutane,bromo-;Cyclobutane, bromo-;Bromocyclobutane,95%;BroMocyclobutane 96%;Bromocyclobutane >Cyclobutylbromide,96%
- CBNumber
- CB2143132
- Molecular Formula
- C4H7Br
- Formula Weight
- 135
- MOL File
- 4399-47-7.mol
Cyclobutyl bromide Property
- Boiling point:
- 108 °C(lit.)
- Density
- 1.434 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.479(lit.)
- Flash point:
- 72 °F
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- color
- Clear colorless
- Water Solubility
- Insoluble
- Sensitive
- Light Sensitive
- BRN
- 1900415
- InChI
- InChI=1S/C4H7Br/c5-4-2-1-3-4/h4H,1-3H2
- InChIKey
- KXVUSQIDCZRUKF-UHFFFAOYSA-N
- SMILES
- C1(Br)CCC1
- CAS DataBase Reference
- 4399-47-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Cyclobutyl bromide(4399-47-7)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 10-36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39-16
- RIDADR
- UN 1993 3/PG 2
- WGK Germany
- 3
- F
- 8
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29038900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 226998
- Product name
- Bromocyclobutane
- Purity
- 96%
- Packaging
- 1g
- Price
- $88.25
- Updated
- 2025/07/31
- Product number
- 226998
- Product name
- Bromocyclobutane
- Purity
- 96%
- Packaging
- 5g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- C0771
- Product name
- Bromocyclobutane
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- C0771
- Product name
- Bromocyclobutane
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- B685023
- Product name
- Bromocyclobutane
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Cyclobutyl bromide Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
Cyclobutyl bromide is a cyclopentyl compound that has an hydroxyl group. It is a potent inhibitor of the CB2 receptor, which is primarily expressed on cells of the immune system. Cyclobutyl bromide has been shown to inhibit the uptake of uv light and also has anti-inflammatory properties. Studies have confirmed that this drug inhibits the production of cytokines and chemokines in chronic bronchitis patients, as well as other inflammatory diseases such as rheumatoid arthritis.
Synthesis
2516-33-8
4399-47-7
7051-34-5
The general procedure for the synthesis of cyclobutyl bromide and bromomethyl cyclopropane using hydroxymethyl cyclopropane as a starting material was as follows: first, a stirrer and thermometer were assembled on a 30 mL three-necked flask. 0.36 g (5.0 mmol) of hydroxymethylcyclopropane and 5 mL of chloroform were added to the flask, and the mixture was subsequently cooled to 10 °C with stirring. Then, 2.77 g (6.5 mmol) of a 19% hydrogen bromide/1,4-dioxane solution was slowly added dropwise. After the dropwise addition, the reaction mixture was heated to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction mixture was analyzed by gas chromatography (GC) to afford cyclobutyl bromide and bromomethyl cyclopropane in 74% overall yield. In addition, the reaction produced bromocyclobutane (9% yield) and 4-bromo-1-butene (2% yield) as isomers.
References
[1] Patent: JP2017/14124, 2017, A. Location in patent: Paragraph 0033
[2] European Journal of Medicinal Chemistry, 1980, vol. 15, # 6, p. 571 - 573
[3] Patent: JP5979791, 2016, B2. Location in patent: Paragraph 0036-0038; 0042-0052
Cyclobutyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclobutyl bromide manufacturers
- Product
- Cyclobutyl bromide 4399-47-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- Cyclobutyl bromide 4399-47-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-02
- Product
- Bromocyclobutane 4399-47-7
- Price
- US $10.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 100kg/week
- Release date
- 2024-10-23