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PHYLLANTHIN

Product Name
PHYLLANTHIN
CAS No.
10351-88-9
Chemical Name
PHYLLANTHIN
Synonyms
NSC 619043;PHYLLANTHIN;Phyllanthin-RM;Subfoliar Pearlin;Phyllanthin (15 mg);PHOSPHO-L-SERINE, O-(RG);Phyllanthin, 10 mM in DMSO;3,3',4,4',9,9'-HexaMethoxylignan;Tetra-O-Methylsecoisolariciresinol;(2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane
CBNumber
CB2143758
Molecular Formula
C24H34O6
Formula Weight
418.52
MOL File
10351-88-9.mol
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PHYLLANTHIN Property

Melting point:
96℃
Boiling point:
530.6±50.0 °C(Predicted)
Density 
1.069
storage temp. 
15-25°C
solubility 
DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form 
Solid
color 
White to off-white
BRN 
2066503
LogP
4.110 (est)
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Safety

WGK Germany 
3
HS Code 
3824999270
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89756
Product name
Phyllanthin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$524
Updated
2025/07/31
Sigma-Aldrich
Product number
1536509
Product name
Phyllanthin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$343
Updated
2025/07/31
Sigma-Aldrich
Product number
75110
Product name
Phyllanthin
Purity
analytical standard
Packaging
10mg
Price
$408
Updated
2022/05/15
Cayman Chemical
Product number
11745
Product name
Phyllanthin
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11745
Product name
Phyllanthin
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2024/03/01
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PHYLLANTHIN Chemical Properties,Usage,Production

Uses

Phyllanthin is a chemical extract from the Phyllanthus niruri plant and displays pharmacological effects as an anti-diabetic action, anti-arthritic, and inhibitor of P-gp.

Definition

ChEBI: Phyllanthin is a lignan.

in vivo

Phyllanthin (10 mg/kg; oral administration; once a day; 30 days) has protective effects in carbon tetrachloride (HY-Y0298) induced hepatotoxicity and experimental liver fibrosis in mice [2].
Phyllanthin (30 mg/kg; oral administration; single dose) exerts anti-tumor effects in diethylnitrosamine (HY-N7434) induced liver carcinogenesis in rats [5].
Phyllanthin (20-100 mg/kg; oral administration; once a day; 14 days) inhibits cellular and humoral immune responses in Balb/C mice [6].

Animal Model:Carbon tetrachloride (HY-Y0298) treated Swiss strain female mice (32-35 g) [2]
Dosage:10 mg/kg
Administration:Oral administration (p.o.); once a day; 30 days
Result:Normalized the level of liver marker enzymes (ALT and AST) and collagen content in hepatotoxicity and experimental liver fibrosis mice.
Restored normal liver architecture, reversed the formation of continuous fibrotic septa between the central and portal veins and nodules.
Reduced the levels of TGF-β1, ALK5, p-Smad2 and p-Smad3 in hepatotoxicity and experimental liver fibrosis mice.
Animal Model:Diethylnitrosamine (Cat. No. HY-N7434) treated male Wistar albino rats (210-230 g)[5]
Dosage:30 mg/kg
Administration:Oral administration (p.o.); single dose
Result:Significantly reduced 8-OHdG levels and delayed the oxidative damage in diethylnitrosamine -induced liver cancer rats.
Significantly reduced liver tissue injury biomarkers (ALT, AST, GGT, ALP and LDH) levels and tumor markers (AFP and CEA).
Reduced cellular enlargement, nodules, and hyperplasiaenlargement in diethylnitrosamine-induced liver tissue.
Animal Model:Male Balb/C mice aged 6-8 weeks old (18-22 g) [6]
Dosage:20 mg/kg, 40 mg/kg, and 100 mg/kg
Administration:Oral administration (p.o.); once a day; 14 days
Result:Dose-dependently inhibited CD11b/CD18 adhesion, the engulfment of E.coli by peritoneal macrophages molecules, NO and MPO release.
Dose-dependently inhibited T and B lymphocytes proliferation and down-regulated Th1 (IL-2 and IFN-γ) and Th2 (IL-4) cytokines.
Dose-dependently inhibited the sheep red blood cell (sRBC)-induced swelling rate of mice paw in delayed type hypersensitivity.
Significantly inhibited the serum levels of ceruloplasmin and lysozyme at higher doses (40 and 100 mg/kg).
Dose-dependently down-regulated anti-sRBC immunoglobulins (IgM and IgG) antibody titer.

PHYLLANTHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PHYLLANTHIN Suppliers

China 90 India 3 United Kingdom 2 United States 9 USA 1 Global 105
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10351-88-9, PHYLLANTHINRelated Search:

Anwuligan Benzoylgomisin O (1S,3aR,4R,6aR)-4-(3,5-Dimethoxyphenyl)tetrahydro-1-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan 4'-Demethylepipodophyllotoxin HYPOPHYLLANTHIN 28-deMethyl -β-aMyrone B-D-GLUCOPYRANOSE 4'-Demethylpodophyllotoxin (-)-Syringaresinol-4-O-beta-D-glucopyranoside EUDESMINE CORILAGIN (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside Gomisin M2 conhydrine (S)-3-METHOXYPYRROLIDINE ETHOXYPYRROLIDINE(S-3-) PHYLLANTHIN 1-isopropylpiperidin-4-ol

  • PHYLLANTHIN
  • PHOSPHO-L-SERINE, O-(RG)
  • 1,1'-[(2S,3S)-2,3-Bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxybenzene]
  • NSC 619043
  • Phyllanthin (15 mg)
  • 3,3',4,4',9,9'-HexaMethoxylignan
  • Tetra-O-Methylsecoisolariciresinol
  • (2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane
  • Subfoliar Pearlin
  • Benzene,1,1'-[(2S,3S)-2,3-bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxy-
  • hepatoprotective,inhibit,bioactive,antioxidative,Phyllanthin,Phyllanthus,Inhibitor,amarus,lignan
  • Phyllanthin-RM
  • Phyllanthin, 10 mM in DMSO
  • 10351-88-9