3-(3-Hydroxyphenyl)benzoic acid
- Product Name
- 3-(3-Hydroxyphenyl)benzoic acid
- CAS No.
- 171047-01-1
- Chemical Name
- 3-(3-Hydroxyphenyl)benzoic acid
- Synonyms
- 3-(3-Hydroxyphenyl)benzoic acid;3'-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylic acid, 3'-hydroxy-;3′-Hydroxy-biphenyl-3-carboxylic acid, CAS 171047-01-1
- CBNumber
- CB21455232
- Molecular Formula
- C13H10O3
- Formula Weight
- 214.22
- MOL File
- 171047-01-1.mol
3-(3-Hydroxyphenyl)benzoic acid Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H817623
- Product name
- 3''-Hydroxy-biphenyl-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- H817623
- Product name
- 3''-Hydroxy-biphenyl-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 8793AA
- Product name
- 3'-Hydroxy-[1,1'-biphenyl]-3-carboxylicacid
- Packaging
- 250mg
- Price
- $137
- Updated
- 2021/12/16
- Product number
- CHM0092567
- Product name
- 3'-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1280.66
- Updated
- 2021/12/16
- Product number
- A378365
- Product name
- 3'-Hydroxy-[1,1'-biphenyl]-3-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
3-(3-Hydroxyphenyl)benzoic acid Chemical Properties,Usage,Production
Synthesis
585-76-2
87199-18-6
171047-01-1
General method: m-Bromobenzoic acid (1.0 eq.) was dissolved in a solvent mixture of water and dioxane (1:1). 3-Hydroxyphenylboronic acid (1.5 eq.) and potassium phosphate (5.0 eq.) were added. The solution was degassed by vacuum/argon cycles (10 times) and further degassed (5 times) before addition of PdCl2(PPh3)2 (10 mol%). The resulting mixture was stirred at 95 °C and under argon atmosphere for 16-20 hours. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth, diluted with water (~30 mL) and then washed with chloroform (3 x 30 mL). The aqueous phase was concentrated under reduced pressure and subsequently purified by a C18 pre-column and further purified on a 10 g or 60 g C18 column using a gradient elution with aqueous acetonitrile (10-100%) to give 3'-hydroxybiphenyl-3-carboxylic acid.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 634 - 648
3-(3-Hydroxyphenyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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